Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4

Lovemore Kunorozva; Dale E Rae; Laura Roden

doi:10.1080/07420528.2022.2139184

Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4

Lovemore Kunorozva, Dale E Rae, Laura Roden

Research output: Contribution to journal › Article › peer-review

103 Downloads (Pure)

Abstract

Inter-individual variability exists in recovery from jetlag following travel across time zones. Part of this variation may be due to genetic differences at the variable number tandem repeat (VNTR) polymorphism of the PERIOD3 (PER3) gene as this polymorphism has been associated with chronotype and sleep, as well as sensitivity to blue light on melatonin suppression. To test this hypothesis we conducted a laboratory-based study to compare re-entrainment in males genotyped as PER34/4 (n=8) and PER35/5 (n=8) following simulated eastward travel across six time zones. The recovery strategy included morning blue-enriched light exposure and appropriately-timed meals during the first 24h after simulated travel. Dim light melatonin onset (DLMO), sleep characteristics, perceived sleepiness levels (Stanford Sleepiness Scale), and resting metabolic parameters were measured during constant routine periods before and after simulated travel. While DLMO time was similar between the two groups prior to simulated eastward travel (p=0.223), it was earlier in the PER35/5 group (17h23 (17h15; 17h37)) than the PER34/4 group (18h05 (17h53; 18h12)) afterwards (p=0.046). During resynchronisation, perceived sleepiness and metabolic parameters were similar to pre-travel in both groups but sleep was more disturbed in the PER35/5 group (total sleep time: p=0.008, sleep efficiency: p=0.008, wake after sleep onset: p=0.023). The PER3 VNTR genotype may influence the efficacy of re-entrainment following trans-meridian travel when blue-enriched light exposure is incorporated into the recovery strategy on the first day following travel.

Original language	English
Pages (from-to)	1611-1623
Number of pages	13
Journal	Chronobiology International
Volume	39
Issue number	12
Early online date	2 Nov 2022
DOIs	https://doi.org/10.1080/07420528.2022.2139184
Publication status	Published - 2 Dec 2022

Bibliographical note

© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited.

Funding

This work was supported by research bursaries to LK from the University of Cape Town (UCT)\u2019s International/Refugee Scholarship and the Molecular & Cell Biology Department\u2019s Equity Development Programme as well as the UCT Research Associate grant. The experimental work was funded by UCT URC Research Development grants to LCR and DER, and a UCT start-up grant to DER. We are grateful to the participants for their time and commitment. The authors would like to thank former members of the Rhythms and Blooms Laboratory Dr Eric Banda, Dr Rob Henst, Dr Rageema Joseph, Chenjerai Muchapirei, Nyambura Shawa and the late Denford Banga, as well as Prof Vicki Lambert, Mrs Hendriena Victor and Dr Jacolene Kroff for their assistance with this study. We are grateful to Granny Goose Duvets, A1 Furnishers and Plumstead Electrical in Cape Town for their sponsorship of bedding, beds and lighting respectively.

Keywords

Phase shift
blue light
circadian rhythm
jetlag
PER3 VNTR polymorphism

Access to Document

10.1080/07420528.2022.2139184Licence: CC BY

PublishedFinal published version, 1.41 MBLicence: CC BY

Cite this

@article{8032256fec9848f2aae2ae4be774fe41,

title = "Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4",

abstract = "Inter-individual variability exists in recovery from jetlag following travel across time zones. Part of this variation may be due to genetic differences at the variable number tandem repeat (VNTR) polymorphism of the PERIOD3 (PER3) gene as this polymorphism has been associated with chronotype and sleep, as well as sensitivity to blue light on melatonin suppression. To test this hypothesis we conducted a laboratory-based study to compare re-entrainment in males genotyped as PER34/4 (n=8) and PER35/5 (n=8) following simulated eastward travel across six time zones. The recovery strategy included morning blue-enriched light exposure and appropriately-timed meals during the first 24h after simulated travel. Dim light melatonin onset (DLMO), sleep characteristics, perceived sleepiness levels (Stanford Sleepiness Scale), and resting metabolic parameters were measured during constant routine periods before and after simulated travel. While DLMO time was similar between the two groups prior to simulated eastward travel (p=0.223), it was earlier in the PER35/5 group (17h23 (17h15; 17h37)) than the PER34/4 group (18h05 (17h53; 18h12)) afterwards (p=0.046). During resynchronisation, perceived sleepiness and metabolic parameters were similar to pre-travel in both groups but sleep was more disturbed in the PER35/5 group (total sleep time: p=0.008, sleep efficiency: p=0.008, wake after sleep onset: p=0.023). The PER3 VNTR genotype may influence the efficacy of re-entrainment following trans-meridian travel when blue-enriched light exposure is incorporated into the recovery strategy on the first day following travel.",

keywords = "Phase shift, blue light, circadian rhythm, jetlag, PER3 VNTR polymorphism",

author = "Lovemore Kunorozva and Rae, \{Dale E\} and Laura Roden",

note = "{\textcopyright} 2022 The Author(s). Published with license by Taylor \& Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",

year = "2022",

month = dec,

day = "2",

doi = "10.1080/07420528.2022.2139184",

language = "English",

volume = "39",

pages = "1611--1623",

journal = "Chronobiology International",

issn = "0742-0528",

publisher = "Taylor and Francis",

number = "12",

}

TY - JOUR

T1 - Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4

AU - Kunorozva, Lovemore

AU - Rae, Dale E

AU - Roden, Laura

N1 - © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2022/12/2

Y1 - 2022/12/2

N2 - Inter-individual variability exists in recovery from jetlag following travel across time zones. Part of this variation may be due to genetic differences at the variable number tandem repeat (VNTR) polymorphism of the PERIOD3 (PER3) gene as this polymorphism has been associated with chronotype and sleep, as well as sensitivity to blue light on melatonin suppression. To test this hypothesis we conducted a laboratory-based study to compare re-entrainment in males genotyped as PER34/4 (n=8) and PER35/5 (n=8) following simulated eastward travel across six time zones. The recovery strategy included morning blue-enriched light exposure and appropriately-timed meals during the first 24h after simulated travel. Dim light melatonin onset (DLMO), sleep characteristics, perceived sleepiness levels (Stanford Sleepiness Scale), and resting metabolic parameters were measured during constant routine periods before and after simulated travel. While DLMO time was similar between the two groups prior to simulated eastward travel (p=0.223), it was earlier in the PER35/5 group (17h23 (17h15; 17h37)) than the PER34/4 group (18h05 (17h53; 18h12)) afterwards (p=0.046). During resynchronisation, perceived sleepiness and metabolic parameters were similar to pre-travel in both groups but sleep was more disturbed in the PER35/5 group (total sleep time: p=0.008, sleep efficiency: p=0.008, wake after sleep onset: p=0.023). The PER3 VNTR genotype may influence the efficacy of re-entrainment following trans-meridian travel when blue-enriched light exposure is incorporated into the recovery strategy on the first day following travel.

AB - Inter-individual variability exists in recovery from jetlag following travel across time zones. Part of this variation may be due to genetic differences at the variable number tandem repeat (VNTR) polymorphism of the PERIOD3 (PER3) gene as this polymorphism has been associated with chronotype and sleep, as well as sensitivity to blue light on melatonin suppression. To test this hypothesis we conducted a laboratory-based study to compare re-entrainment in males genotyped as PER34/4 (n=8) and PER35/5 (n=8) following simulated eastward travel across six time zones. The recovery strategy included morning blue-enriched light exposure and appropriately-timed meals during the first 24h after simulated travel. Dim light melatonin onset (DLMO), sleep characteristics, perceived sleepiness levels (Stanford Sleepiness Scale), and resting metabolic parameters were measured during constant routine periods before and after simulated travel. While DLMO time was similar between the two groups prior to simulated eastward travel (p=0.223), it was earlier in the PER35/5 group (17h23 (17h15; 17h37)) than the PER34/4 group (18h05 (17h53; 18h12)) afterwards (p=0.046). During resynchronisation, perceived sleepiness and metabolic parameters were similar to pre-travel in both groups but sleep was more disturbed in the PER35/5 group (total sleep time: p=0.008, sleep efficiency: p=0.008, wake after sleep onset: p=0.023). The PER3 VNTR genotype may influence the efficacy of re-entrainment following trans-meridian travel when blue-enriched light exposure is incorporated into the recovery strategy on the first day following travel.

KW - Phase shift

KW - blue light

KW - circadian rhythm

KW - jetlag

KW - PER3 VNTR polymorphism

UR - https://www.scopus.com/pages/publications/85141342888

U2 - 10.1080/07420528.2022.2139184

DO - 10.1080/07420528.2022.2139184

M3 - Article

SN - 0742-0528

VL - 39

SP - 1611

EP - 1623

JO - Chronobiology International

JF - Chronobiology International

IS - 12

ER -

Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this