Differential effects of anxiety and autism on social scene scanning in males with fragile X syndrome

Hayley Crawford, Joanna Moss, Chris Oliver, Deborah Riby

    Research output: Research - peer-reviewArticle

    Abstract

    Background: Existing literature draws links between social attention and socio-behavioural profiles in neurodevelopmental disorders. Fragile X syndrome (FXS) is associated with a known socio-behavioural phenotype of social anxiety and social communication difficulties alongside high social motivation. However, studies investigating social attention in males with FXS are scarce. Using eye-tracking, this study investigates social attention and its relationship with both anxiety and autism symptomatology in males with FXS.Methods: We compared dwell times to the background, body, and face regions of naturalistic social scenes in 11 males with FXS (Mage = 26.29) and 11 typically developing (TD) children who were matched on gender, and receptive language ability (Mage = 6.28). Using informant-report measures, we then investigated the relationships between social scene scanning and anxiety, and social scene scanning and social communicative impairments. Results: Males with FXS did not differ to TD children on overall dwell time to the background, body or face regions of the naturalistic social scenes. Whilst males with FXS displayed developmentally ‘typical’ social attention, increased looking at faces was associated with both heightened anxiety and fewer social communication impairments in this group. Conclusions: These results offer novel insights into the mechanisms associated with social attention in FXS, and provide evidence to suggest that anxiety and autism symptomatology, which are both heightened in FXS, have differential effects on social attention.

    Publisher Statement: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
    LanguageEnglish
    Article number9
    Number of pages10
    JournalJournal of Neurodevelopmental Disorders
    Volume9
    DOIs
    StatePublished - 25 Sep 2017

    Fingerprint

    Fragile X Syndrome
    Anxiety
    Licensure
    Communication
    Body Regions
    Public Sector
    Anniversaries and Special Events
    Reproduction
    Motivation
    Phenotype

    Keywords

    • Eye-tracking
    • fragile X syndrome
    • autism spectrum disorder
    • anxiety
    • social attention

    Cite this

    Differential effects of anxiety and autism on social scene scanning in males with fragile X syndrome. / Crawford, Hayley; Moss, Joanna; Oliver, Chris; Riby, Deborah.

    In: Journal of Neurodevelopmental Disorders, Vol. 9, 9, 25.09.2017.

    Research output: Research - peer-reviewArticle

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    abstract = "Background: Existing literature draws links between social attention and socio-behavioural profiles in neurodevelopmental disorders. Fragile X syndrome (FXS) is associated with a known socio-behavioural phenotype of social anxiety and social communication difficulties alongside high social motivation. However, studies investigating social attention in males with FXS are scarce. Using eye-tracking, this study investigates social attention and its relationship with both anxiety and autism symptomatology in males with FXS.Methods: We compared dwell times to the background, body, and face regions of naturalistic social scenes in 11 males with FXS (Mage = 26.29) and 11 typically developing (TD) children who were matched on gender, and receptive language ability (Mage = 6.28). Using informant-report measures, we then investigated the relationships between social scene scanning and anxiety, and social scene scanning and social communicative impairments. Results: Males with FXS did not differ to TD children on overall dwell time to the background, body or face regions of the naturalistic social scenes. Whilst males with FXS displayed developmentally ‘typical’ social attention, increased looking at faces was associated with both heightened anxiety and fewer social communication impairments in this group. Conclusions: These results offer novel insights into the mechanisms associated with social attention in FXS, and provide evidence to suggest that anxiety and autism symptomatology, which are both heightened in FXS, have differential effects on social attention.Publisher Statement: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.",
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    author = "Hayley Crawford and Joanna Moss and Chris Oliver and Deborah Riby",
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    AB - Background: Existing literature draws links between social attention and socio-behavioural profiles in neurodevelopmental disorders. Fragile X syndrome (FXS) is associated with a known socio-behavioural phenotype of social anxiety and social communication difficulties alongside high social motivation. However, studies investigating social attention in males with FXS are scarce. Using eye-tracking, this study investigates social attention and its relationship with both anxiety and autism symptomatology in males with FXS.Methods: We compared dwell times to the background, body, and face regions of naturalistic social scenes in 11 males with FXS (Mage = 26.29) and 11 typically developing (TD) children who were matched on gender, and receptive language ability (Mage = 6.28). Using informant-report measures, we then investigated the relationships between social scene scanning and anxiety, and social scene scanning and social communicative impairments. Results: Males with FXS did not differ to TD children on overall dwell time to the background, body or face regions of the naturalistic social scenes. Whilst males with FXS displayed developmentally ‘typical’ social attention, increased looking at faces was associated with both heightened anxiety and fewer social communication impairments in this group. Conclusions: These results offer novel insights into the mechanisms associated with social attention in FXS, and provide evidence to suggest that anxiety and autism symptomatology, which are both heightened in FXS, have differential effects on social attention.Publisher Statement: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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    KW - fragile X syndrome

    KW - autism spectrum disorder

    KW - anxiety

    KW - social attention

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