Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy

Robyn J Tapp, Andrew Sharp, Alice V Stanton, Eoin O'Brien, Nishi Chaturvedi, Neil R Poulter, Peter S Sever, Simon A McG Thom, Alun D Hughes, Jamil Mayet, ASCOT Investigators

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


OBJECTIVES: We hypothesized that an amlodipine-based regimen would have more favorable effects on left ventricular (LV) diastolic function.

BACKGROUND: Different antihypertensive therapies may vary in their effect on LV diastolic function.

METHODS: The HACVD (Hypertension Associated Cardiovascular Disease) substudy of ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) collected detailed cardiovascular phenotypic data on a subset of 1,006 participants recruited from 2 centers (St. Mary's Hospital, London, and Beaumont Hospital, Dublin). Conventional and tissue Doppler echocardiography and measurement of plasma B-type natriuretic peptide (BNP) were performed approximately 1 year after randomization to atenolol-based or amlodipine-based antihypertensive treatment to assess LV diastolic function.

RESULTS: On-treatment blood pressure (BP) (mean +/- SD) was similar in both groups: atenolol-based regimen, systolic BP of 137 +/- 17 mm Hg, diastolic BP of 82 +/- 9 mm Hg; amlodipine-based regimen, systolic BP of 136 +/- 15 mm Hg, diastolic BP of 80 +/- 9 mm Hg. Ejection fraction did not differ between groups, but early diastolic mitral annular velocity (E'), a measure of diastolic relaxation, was lower in patients on the atenolol-based regimen: atenolol-based regimen, 7.9 +/- 1.8; amlodipine-based regimen, 8.8 +/- 2.0. A measure of left ventricular filling pressure, E/E', and BNP were significantly higher in patients on the atenolol-based regimen. Differences in E', E/E', and BNP remained significant after adjustment for age and sex. Further adjustment for systolic BP, LV mass index, and heart rate had no impact on differences in mean E' or BNP. The difference in E/E' was attenuated.

CONCLUSIONS: Patients receiving treatment with an amlodipine-based regimen had better diastolic function than patients treated with the atenolol-based regimen. Treatment-related differences in diastolic function were independent of BP reduction and other factors that are known to affect diastolic function.

Original languageEnglish
Pages (from-to)1875-1881
Number of pages7
JournalJournal of the American College of Cardiology
Issue number17
Early online date20 Apr 2010
Publication statusPublished - 27 Apr 2010
Externally publishedYes

Bibliographical note

Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.


  • Amlodipine/pharmacology
  • Antihypertensive Agents/pharmacology
  • Atenolol/pharmacology
  • Blood Pressure/drug effects
  • Diastole/drug effects
  • Echocardiography, Doppler
  • Female
  • Humans
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain/blood
  • Ventricular Function, Left/drug effects


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