Differences in turnover between thymic medullary dendritic cells and a subset of cortical macrophages

J. Kampinga, P. Nieuwenhuis, B. Roser, R. Aspinall

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To investigate the turnover of thymic accessory cells, we performed vascular thymus transplantation in RT7 congenic rats. mAb specific for one of the two allelic variants of the RT7 molecule, as well as mAb specific for either medullary interdigitating cells or a subset of cortical macrophages (M∅), were used on cryostat sections and cell suspensions prepared from grafted thymuses to monitor the turnover of these two cell types. In contrast to the complete turnover of interdigitating cells within 3 wk after transplantation, ED2-labeled cortical M∅ showed a very slow turnover. Seventy-six days after transplantation, more than 30% of these M∅ were found to be still of donor origin. The different turnover rates of these thymic accessory cells could reflect their function in T cell development.

Original languageEnglish
Pages (from-to)1659-1663
Number of pages5
JournalJournal of Immunology
Issue number6
Publication statusPublished - 1990
Externally publishedYes


ASJC Scopus subject areas

  • Immunology

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