Dietary total antioxidant capacity and risk of ulcerative colitis: a case–control study

Jamal Rahmani, Hamed Kord-Varkaneh, Paul Ryan, Cain Clark, Andrew S Day, Azita Hekmatdoost

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    Objective: Data on the association between the antioxidant capacity of a diet and the risk of ulcerative colitis (UC) are scarce. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of UC in Iranian adults. Methods: In this case-control study, patients with UC and age-matched healthy controls were recruited from a hospital clinic. All participants completed a validated 168-item food frequency questionnaire, the results of which were subsequently used to generate dietary TAC. Ferric reducing-antioxidant power values were used to calculate dietary TAC. Results: Altogether 62 patients with UC and 124 healthy controls were enrolled. UC patients had a higher calorific intake (P < 0.01), and consumed more monounsaturated fatty acids (P < 0.01), vitamin B 9 (P < 0.01) and calcium (P = 0.02) compared with healthy controls, while the control group had a higher vitamin C intake than the participants with UC (P < 0.01). In a fully adjusted model, participants who were in the highest quartile of dietary TAC had a lower risk of UC (odds ratio 0.11, 95% confidence interval 0.01-0.73). Conclusions: A higher dietary TAC score was associated with lower odds of UC in this case-control study. Further elucidation of the role of key dietary elements is now warranted.

    Original languageEnglish
    Pages (from-to)636-641
    Number of pages6
    JournalJournal of Digestive Diseases
    Issue number12
    Early online date30 Sept 2019
    Publication statusPublished - 1 Dec 2019

    Bibliographical note

    This is the peer reviewed version of the following articleRahmani, J, Kord-Varkaneh, H, Ryan, P, Clark, C, Day, AS & Hekmatdoost, A 2019, 'Dietary total antioxidant capacity and risk of ulcerative colitis: a case–control study', Journal of Digestive Diseases, vol. 20, no. 12, pp. 636-641., which has been published in final form at
    This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.


    • dietary total antioxidant capacity
    • ulcerative colitis
    • TAC
    • diet


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