Dietary nutrient patterns and the risk of colorectal cancer and colorectal adenomas: a case-control study

Saeede Jafari Nasab, Matin Ghanavati, Alireza Bahrami, Pegah Rafiee, Amir Sadeghi, Cain C T Clark, Golbon Sohrab, Anahita Hoshyarrad, Ehsan Hejazi

Research output: Contribution to journalArticle

Abstract

Although the association between food patterns and the risk of colorectal cancer (CRC) and colorectal adenomas (CRA) has been explored previously, a distinct paucity of studies has evaluated the association of nutrient pattern and the risk of CRC and CRA as precursors of CRC. Thus, the purpose of this case-control study was to investigate nutrient patterns and their relationship with CRC and CRA in Iran. Two hundred forty hospital control, 129 newly diagnosed CRC and 130 newly diagnosed CRA patients were asked about their dietary intakes using validated questionnaires. To define the major nutrient patterns, principal component analysis was applied based on preselected nutrients, and four explainable nutrient patterns were obtained: Factor 1 (mixed), factor 2 (the antioxidant), factor 3 (dairy) and factor 4 (the high fat). Logistic regression was used to determine odds ratios (OR) with 95% confidence interval (CI) of CRC and CRA according to categories of nutrient patterns. After adjusting for confounders, factor 2 was significantly associated with lower risk for the CRC and CRA in the second category compared with the first, respectively (OR = 0.20, 95% CI: 0.12-0.34, OR = 0.34, 95% CI: 0.21-0.56). Participants in the highest category of factor 4 showed an increase in the risk of CRC and CRA, respectively, than those in the low category, in both crude and multivariate analysis (OR = 1.77, 95% CI: 1.57-2.95, OR = 1.85, 95% CI: 1.13-3.02). Among derived nutrient patterns, 'the antioxidant pattern' was inversely associated with CRC/CRA, whilst 'high fat pattern' showed a direct association with these diseases.

Original languageEnglish
Pages (from-to)(In-Press)
JournalEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
Volume(In-Press)
Early online date7 Feb 2020
DOIs
Publication statusE-pub ahead of print - 7 Feb 2020

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