Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition

Sascha Abbas; Jakob Linseisen; Sabine Rohrmann; Jenny Chang-Claude; Petra H. Peeters; Pierre Engel; Magritt Brustad; Eiliv Lund; Guri Skeie; Anja Olsen; Anne Tjønneland; Kim Overvad; Marie Christine Boutron-Ruault; Francoise Clavel-Chapelon; Guy Fagherazzi; Rudolf Kaaks; Heiner Boeing; Brian Buijsse; George Adarakis; Vassilis Ouranos; Antonia Trichopoulou; Giovanna Masala; Vittorio Krogh; Amalia Mattiello; Rosario Tumino; Carlotta Sacerdote; Genevieve Buckland; Marcial Vicente Argüelles Suárez; Maria José Sánchez; Maria Dolores Chirlaque; Aurelio Barricarte; Pilar Amiano; Jonas Manjer; Elisabet Wirfält; Per Lenner; Malin Sund; H. B. Bueno-De-Mesquita; Fränzel J B Van Duijnhoven; Kay Tee Khaw; Nick Wareham; Timothy J. Key; Veronika Fedirko; Isabelle Romieu; Valentina Gallo; Teresa Norat; Petra A. Wark; Elio Riboli

doi:10.1080/01635581.2013.752018

Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition

Sascha Abbas, Jakob Linseisen, Sabine Rohrmann, Jenny Chang-Claude, Petra H. Peeters, Pierre Engel, Magritt Brustad, Eiliv Lund, Guri Skeie, Anja Olsen, Anne Tjønneland, Kim Overvad, Marie Christine Boutron-Ruault, Francoise Clavel-Chapelon, Guy Fagherazzi, Rudolf Kaaks, Heiner Boeing, Brian Buijsse, George Adarakis, Vassilis OuranosAntonia Trichopoulou, Giovanna Masala, Vittorio Krogh, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, Genevieve Buckland, Marcial Vicente Argüelles Suárez, Maria José Sánchez, Maria Dolores Chirlaque, Aurelio Barricarte, Pilar Amiano, Jonas Manjer, Elisabet Wirfält, Per Lenner, Malin Sund, H. B. Bueno-De-Mesquita, Fränzel J B Van Duijnhoven, Kay Tee Khaw, Nick Wareham, Timothy J. Key, Veronika Fedirko, Isabelle Romieu, Valentina Gallo, Teresa Norat, Petra A. Wark, Elio Riboli

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (P_trend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (P_interaction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.

Original language	English
Pages (from-to)	178-187
Number of pages	10
Journal	Nutrition and Cancer
Volume	65
Issue number	2
Early online date	26 Feb 2013
DOIs	https://doi.org/10.1080/01635581.2013.752018
Publication status	Published - 2013

ASJC Scopus subject areas

Medicine (miscellaneous)
Oncology
Nutrition and Dietetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/01635581.2013.752018

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Abbas, S., Linseisen, J., Rohrmann, S., Chang-Claude, J., Peeters, P. H., Engel, P., Brustad, M., Lund, E., Skeie, G., Olsen, A., Tjønneland, A., Overvad, K., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, G., Kaaks, R., Boeing, H., Buijsse, B., Adarakis, G., ... Riboli, E. (2013). Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition. Nutrition and Cancer, 65(2), 178-187. https://doi.org/10.1080/01635581.2013.752018

Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition. / Abbas, Sascha; Linseisen, Jakob; Rohrmann, Sabine; Chang-Claude, Jenny; Peeters, Petra H.; Engel, Pierre; Brustad, Magritt; Lund, Eiliv; Skeie, Guri; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Francoise; Fagherazzi, Guy; Kaaks, Rudolf; Boeing, Heiner; Buijsse, Brian; Adarakis, George; Ouranos, Vassilis; Trichopoulou, Antonia; Masala, Giovanna; Krogh, Vittorio; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Buckland, Genevieve; Suárez, Marcial Vicente Argüelles; Sánchez, Maria José; Chirlaque, Maria Dolores; Barricarte, Aurelio; Amiano, Pilar; Manjer, Jonas; Wirfält, Elisabet; Lenner, Per; Sund, Malin; Bueno-De-Mesquita, H. B.; Van Duijnhoven, Fränzel J B; Khaw, Kay Tee; Wareham, Nick; Key, Timothy J.; Fedirko, Veronika; Romieu, Isabelle; Gallo, Valentina; Norat, Teresa; Wark, Petra A.; Riboli, Elio.

In: Nutrition and Cancer, Vol. 65, No. 2, 2013, p. 178-187.

Research output: Contribution to journal › Article › peer-review

Abbas, S, Linseisen, J, Rohrmann, S, Chang-Claude, J, Peeters, PH, Engel, P, Brustad, M, Lund, E, Skeie, G, Olsen, A, Tjønneland, A, Overvad, K, Boutron-Ruault, MC, Clavel-Chapelon, F, Fagherazzi, G, Kaaks, R, Boeing, H, Buijsse, B, Adarakis, G, Ouranos, V, Trichopoulou, A, Masala, G, Krogh, V, Mattiello, A, Tumino, R, Sacerdote, C, Buckland, G, Suárez, MVA, Sánchez, MJ, Chirlaque, MD, Barricarte, A, Amiano, P, Manjer, J, Wirfält, E, Lenner, P, Sund, M, Bueno-De-Mesquita, HB, Van Duijnhoven, FJB, Khaw, KT, Wareham, N, Key, TJ, Fedirko, V, Romieu, I, Gallo, V, Norat, T, Wark, PA & Riboli, E 2013, 'Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition', Nutrition and Cancer, vol. 65, no. 2, pp. 178-187. https://doi.org/10.1080/01635581.2013.752018

Abbas, Sascha ; Linseisen, Jakob ; Rohrmann, Sabine ; Chang-Claude, Jenny ; Peeters, Petra H. ; Engel, Pierre ; Brustad, Magritt ; Lund, Eiliv ; Skeie, Guri ; Olsen, Anja ; Tjønneland, Anne ; Overvad, Kim ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Francoise ; Fagherazzi, Guy ; Kaaks, Rudolf ; Boeing, Heiner ; Buijsse, Brian ; Adarakis, George ; Ouranos, Vassilis ; Trichopoulou, Antonia ; Masala, Giovanna ; Krogh, Vittorio ; Mattiello, Amalia ; Tumino, Rosario ; Sacerdote, Carlotta ; Buckland, Genevieve ; Suárez, Marcial Vicente Argüelles ; Sánchez, Maria José ; Chirlaque, Maria Dolores ; Barricarte, Aurelio ; Amiano, Pilar ; Manjer, Jonas ; Wirfält, Elisabet ; Lenner, Per ; Sund, Malin ; Bueno-De-Mesquita, H. B. ; Van Duijnhoven, Fränzel J B ; Khaw, Kay Tee ; Wareham, Nick ; Key, Timothy J. ; Fedirko, Veronika ; Romieu, Isabelle ; Gallo, Valentina ; Norat, Teresa ; Wark, Petra A. ; Riboli, Elio. / Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition. In: Nutrition and Cancer. 2013 ; Vol. 65, No. 2. pp. 178-187.

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abstract = "Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.",

author = "Sascha Abbas and Jakob Linseisen and Sabine Rohrmann and Jenny Chang-Claude and Peeters, {Petra H.} and Pierre Engel and Magritt Brustad and Eiliv Lund and Guri Skeie and Anja Olsen and Anne Tj{\o}nneland and Kim Overvad and Boutron-Ruault, {Marie Christine} and Francoise Clavel-Chapelon and Guy Fagherazzi and Rudolf Kaaks and Heiner Boeing and Brian Buijsse and George Adarakis and Vassilis Ouranos and Antonia Trichopoulou and Giovanna Masala and Vittorio Krogh and Amalia Mattiello and Rosario Tumino and Carlotta Sacerdote and Genevieve Buckland and Su{\'a}rez, {Marcial Vicente Arg{\"u}elles} and S{\'a}nchez, {Maria Jos{\'e}} and Chirlaque, {Maria Dolores} and Aurelio Barricarte and Pilar Amiano and Jonas Manjer and Elisabet Wirf{\"a}lt and Per Lenner and Malin Sund and Bueno-De-Mesquita, {H. B.} and {Van Duijnhoven}, {Fr{\"a}nzel J B} and Khaw, {Kay Tee} and Nick Wareham and Key, {Timothy J.} and Veronika Fedirko and Isabelle Romieu and Valentina Gallo and Teresa Norat and Wark, {Petra A.} and Elio Riboli",

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AU - Abbas, Sascha

AU - Linseisen, Jakob

AU - Rohrmann, Sabine

AU - Chang-Claude, Jenny

AU - Peeters, Petra H.

AU - Engel, Pierre

AU - Brustad, Magritt

AU - Lund, Eiliv

AU - Skeie, Guri

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Francoise

AU - Fagherazzi, Guy

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Buijsse, Brian

AU - Adarakis, George

AU - Ouranos, Vassilis

AU - Trichopoulou, Antonia

AU - Masala, Giovanna

AU - Krogh, Vittorio

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Buckland, Genevieve

AU - Suárez, Marcial Vicente Argüelles

AU - Sánchez, Maria José

AU - Chirlaque, Maria Dolores

AU - Barricarte, Aurelio

AU - Amiano, Pilar

AU - Manjer, Jonas

AU - Wirfält, Elisabet

AU - Lenner, Per

AU - Sund, Malin

AU - Bueno-De-Mesquita, H. B.

AU - Van Duijnhoven, Fränzel J B

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Key, Timothy J.

AU - Fedirko, Veronika

AU - Romieu, Isabelle

AU - Gallo, Valentina

AU - Norat, Teresa

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AU - Riboli, Elio

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AB - Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.

U2 - 10.1080/01635581.2013.752018

DO - 10.1080/01635581.2013.752018

M3 - Article

C2 - 23441605

AN - SCOPUS:84874582812

VL - 65

SP - 178

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JO - Nutrition and Cancer

JF - Nutrition and Cancer

SN - 0163-5581

IS - 2

ER -

Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition

Abstract

ASJC Scopus subject areas

UN SDGs

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