Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition

Sascha Abbas, Jakob Linseisen, Sabine Rohrmann, Jenny Chang-Claude, Petra H. Peeters, Pierre Engel, Magritt Brustad, Eiliv Lund, Guri Skeie, Anja Olsen, Anne Tjønneland, Kim Overvad, Marie Christine Boutron-Ruault, Francoise Clavel-Chapelon, Guy Fagherazzi, Rudolf Kaaks, Heiner Boeing, Brian Buijsse, George Adarakis, Vassilis Ouranos & 27 others Antonia Trichopoulou, Giovanna Masala, Vittorio Krogh, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, Genevieve Buckland, Marcial Vicente Argüelles Suárez, Maria José Sánchez, Maria Dolores Chirlaque, Aurelio Barricarte, Pilar Amiano, Jonas Manjer, Elisabet Wirfält, Per Lenner, Malin Sund, H. B. Bueno-De-Mesquita, Fränzel J B Van Duijnhoven, Kay Tee Khaw, Nick Wareham, Timothy J. Key, Veronika Fedirko, Isabelle Romieu, Valentina Gallo, Teresa Norat, Petra A. Wark, Elio Riboli

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.

    Original languageEnglish
    Pages (from-to)178-187
    Number of pages10
    JournalNutrition and Cancer
    Volume65
    Issue number2
    Early online date26 Feb 2013
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Vitamin D
    Breast Neoplasms
    Calcium
    Neoplasms
    Confidence Intervals

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Oncology
    • Nutrition and Dietetics
    • Cancer Research

    Cite this

    Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition. / Abbas, Sascha; Linseisen, Jakob; Rohrmann, Sabine; Chang-Claude, Jenny; Peeters, Petra H.; Engel, Pierre; Brustad, Magritt; Lund, Eiliv; Skeie, Guri; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Francoise; Fagherazzi, Guy; Kaaks, Rudolf; Boeing, Heiner; Buijsse, Brian; Adarakis, George; Ouranos, Vassilis; Trichopoulou, Antonia; Masala, Giovanna; Krogh, Vittorio; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Buckland, Genevieve; Suárez, Marcial Vicente Argüelles; Sánchez, Maria José; Chirlaque, Maria Dolores; Barricarte, Aurelio; Amiano, Pilar; Manjer, Jonas; Wirfält, Elisabet; Lenner, Per; Sund, Malin; Bueno-De-Mesquita, H. B.; Van Duijnhoven, Fränzel J B; Khaw, Kay Tee; Wareham, Nick; Key, Timothy J.; Fedirko, Veronika; Romieu, Isabelle; Gallo, Valentina; Norat, Teresa; Wark, Petra A.; Riboli, Elio.

    In: Nutrition and Cancer, Vol. 65, No. 2, 2013, p. 178-187.

    Research output: Contribution to journalArticle

    Abbas, S, Linseisen, J, Rohrmann, S, Chang-Claude, J, Peeters, PH, Engel, P, Brustad, M, Lund, E, Skeie, G, Olsen, A, Tjønneland, A, Overvad, K, Boutron-Ruault, MC, Clavel-Chapelon, F, Fagherazzi, G, Kaaks, R, Boeing, H, Buijsse, B, Adarakis, G, Ouranos, V, Trichopoulou, A, Masala, G, Krogh, V, Mattiello, A, Tumino, R, Sacerdote, C, Buckland, G, Suárez, MVA, Sánchez, MJ, Chirlaque, MD, Barricarte, A, Amiano, P, Manjer, J, Wirfält, E, Lenner, P, Sund, M, Bueno-De-Mesquita, HB, Van Duijnhoven, FJB, Khaw, KT, Wareham, N, Key, TJ, Fedirko, V, Romieu, I, Gallo, V, Norat, T, Wark, PA & Riboli, E 2013, 'Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition' Nutrition and Cancer, vol. 65, no. 2, pp. 178-187. https://doi.org/10.1080/01635581.2013.752018
    Abbas, Sascha ; Linseisen, Jakob ; Rohrmann, Sabine ; Chang-Claude, Jenny ; Peeters, Petra H. ; Engel, Pierre ; Brustad, Magritt ; Lund, Eiliv ; Skeie, Guri ; Olsen, Anja ; Tjønneland, Anne ; Overvad, Kim ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Francoise ; Fagherazzi, Guy ; Kaaks, Rudolf ; Boeing, Heiner ; Buijsse, Brian ; Adarakis, George ; Ouranos, Vassilis ; Trichopoulou, Antonia ; Masala, Giovanna ; Krogh, Vittorio ; Mattiello, Amalia ; Tumino, Rosario ; Sacerdote, Carlotta ; Buckland, Genevieve ; Suárez, Marcial Vicente Argüelles ; Sánchez, Maria José ; Chirlaque, Maria Dolores ; Barricarte, Aurelio ; Amiano, Pilar ; Manjer, Jonas ; Wirfält, Elisabet ; Lenner, Per ; Sund, Malin ; Bueno-De-Mesquita, H. B. ; Van Duijnhoven, Fränzel J B ; Khaw, Kay Tee ; Wareham, Nick ; Key, Timothy J. ; Fedirko, Veronika ; Romieu, Isabelle ; Gallo, Valentina ; Norat, Teresa ; Wark, Petra A. ; Riboli, Elio. / Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition. In: Nutrition and Cancer. 2013 ; Vol. 65, No. 2. pp. 178-187.
    @article{ac40ab34a64f47269db126da04517ee6,
    title = "Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition",
    abstract = "Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95{\%} confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95{\%} CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95{\%} CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.",
    author = "Sascha Abbas and Jakob Linseisen and Sabine Rohrmann and Jenny Chang-Claude and Peeters, {Petra H.} and Pierre Engel and Magritt Brustad and Eiliv Lund and Guri Skeie and Anja Olsen and Anne Tj{\o}nneland and Kim Overvad and Boutron-Ruault, {Marie Christine} and Francoise Clavel-Chapelon and Guy Fagherazzi and Rudolf Kaaks and Heiner Boeing and Brian Buijsse and George Adarakis and Vassilis Ouranos and Antonia Trichopoulou and Giovanna Masala and Vittorio Krogh and Amalia Mattiello and Rosario Tumino and Carlotta Sacerdote and Genevieve Buckland and Su{\'a}rez, {Marcial Vicente Arg{\"u}elles} and S{\'a}nchez, {Maria Jos{\'e}} and Chirlaque, {Maria Dolores} and Aurelio Barricarte and Pilar Amiano and Jonas Manjer and Elisabet Wirf{\"a}lt and Per Lenner and Malin Sund and Bueno-De-Mesquita, {H. B.} and {Van Duijnhoven}, {Fr{\"a}nzel J B} and Khaw, {Kay Tee} and Nick Wareham and Key, {Timothy J.} and Veronika Fedirko and Isabelle Romieu and Valentina Gallo and Teresa Norat and Wark, {Petra A.} and Elio Riboli",
    year = "2013",
    doi = "10.1080/01635581.2013.752018",
    language = "English",
    volume = "65",
    pages = "178--187",
    journal = "Nutrition and Cancer",
    issn = "0163-5581",
    publisher = "Taylor & Francis",
    number = "2",

    }

    TY - JOUR

    T1 - Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition

    AU - Abbas, Sascha

    AU - Linseisen, Jakob

    AU - Rohrmann, Sabine

    AU - Chang-Claude, Jenny

    AU - Peeters, Petra H.

    AU - Engel, Pierre

    AU - Brustad, Magritt

    AU - Lund, Eiliv

    AU - Skeie, Guri

    AU - Olsen, Anja

    AU - Tjønneland, Anne

    AU - Overvad, Kim

    AU - Boutron-Ruault, Marie Christine

    AU - Clavel-Chapelon, Francoise

    AU - Fagherazzi, Guy

    AU - Kaaks, Rudolf

    AU - Boeing, Heiner

    AU - Buijsse, Brian

    AU - Adarakis, George

    AU - Ouranos, Vassilis

    AU - Trichopoulou, Antonia

    AU - Masala, Giovanna

    AU - Krogh, Vittorio

    AU - Mattiello, Amalia

    AU - Tumino, Rosario

    AU - Sacerdote, Carlotta

    AU - Buckland, Genevieve

    AU - Suárez, Marcial Vicente Argüelles

    AU - Sánchez, Maria José

    AU - Chirlaque, Maria Dolores

    AU - Barricarte, Aurelio

    AU - Amiano, Pilar

    AU - Manjer, Jonas

    AU - Wirfält, Elisabet

    AU - Lenner, Per

    AU - Sund, Malin

    AU - Bueno-De-Mesquita, H. B.

    AU - Van Duijnhoven, Fränzel J B

    AU - Khaw, Kay Tee

    AU - Wareham, Nick

    AU - Key, Timothy J.

    AU - Fedirko, Veronika

    AU - Romieu, Isabelle

    AU - Gallo, Valentina

    AU - Norat, Teresa

    AU - Wark, Petra A.

    AU - Riboli, Elio

    PY - 2013

    Y1 - 2013

    N2 - Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.

    AB - Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.

    U2 - 10.1080/01635581.2013.752018

    DO - 10.1080/01635581.2013.752018

    M3 - Article

    VL - 65

    SP - 178

    EP - 187

    JO - Nutrition and Cancer

    JF - Nutrition and Cancer

    SN - 0163-5581

    IS - 2

    ER -