Abstract
Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.
| Original language | English |
|---|---|
| Pages (from-to) | 178-187 |
| Number of pages | 10 |
| Journal | Nutrition and Cancer |
| Volume | 65 |
| Issue number | 2 |
| Early online date | 26 Feb 2013 |
| DOIs | |
| Publication status | Published - 2013 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Oncology
- Nutrition and Dietetics
- Cancer Research
Cite this
Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition. / Abbas, Sascha; Linseisen, Jakob; Rohrmann, Sabine; Chang-Claude, Jenny; Peeters, Petra H.; Engel, Pierre; Brustad, Magritt; Lund, Eiliv; Skeie, Guri; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Francoise; Fagherazzi, Guy; Kaaks, Rudolf; Boeing, Heiner; Buijsse, Brian; Adarakis, George; Ouranos, Vassilis; Trichopoulou, Antonia; Masala, Giovanna; Krogh, Vittorio; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Buckland, Genevieve; Suárez, Marcial Vicente Argüelles; Sánchez, Maria José; Chirlaque, Maria Dolores; Barricarte, Aurelio; Amiano, Pilar; Manjer, Jonas; Wirfält, Elisabet; Lenner, Per; Sund, Malin; Bueno-De-Mesquita, H. B.; Van Duijnhoven, Fränzel J B; Khaw, Kay Tee; Wareham, Nick; Key, Timothy J.; Fedirko, Veronika; Romieu, Isabelle; Gallo, Valentina; Norat, Teresa; Wark, Petra A.; Riboli, Elio.
In: Nutrition and Cancer, Vol. 65, No. 2, 2013, p. 178-187.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition
AU - Abbas, Sascha
AU - Linseisen, Jakob
AU - Rohrmann, Sabine
AU - Chang-Claude, Jenny
AU - Peeters, Petra H.
AU - Engel, Pierre
AU - Brustad, Magritt
AU - Lund, Eiliv
AU - Skeie, Guri
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Francoise
AU - Fagherazzi, Guy
AU - Kaaks, Rudolf
AU - Boeing, Heiner
AU - Buijsse, Brian
AU - Adarakis, George
AU - Ouranos, Vassilis
AU - Trichopoulou, Antonia
AU - Masala, Giovanna
AU - Krogh, Vittorio
AU - Mattiello, Amalia
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Buckland, Genevieve
AU - Suárez, Marcial Vicente Argüelles
AU - Sánchez, Maria José
AU - Chirlaque, Maria Dolores
AU - Barricarte, Aurelio
AU - Amiano, Pilar
AU - Manjer, Jonas
AU - Wirfält, Elisabet
AU - Lenner, Per
AU - Sund, Malin
AU - Bueno-De-Mesquita, H. B.
AU - Van Duijnhoven, Fränzel J B
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Key, Timothy J.
AU - Fedirko, Veronika
AU - Romieu, Isabelle
AU - Gallo, Valentina
AU - Norat, Teresa
AU - Wark, Petra A.
AU - Riboli, Elio
PY - 2013
Y1 - 2013
N2 - Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.
AB - Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.
U2 - 10.1080/01635581.2013.752018
DO - 10.1080/01635581.2013.752018
M3 - Article
VL - 65
SP - 178
EP - 187
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 2
ER -