TY - JOUR
T1 - Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC)
AU - Murphy, Neil
AU - Norat, Teresa
AU - Ferrari, Pietro
AU - Jenab, Mazda
AU - Bueno-de-Mesquita, Bas
AU - Skeie, Guri
AU - Dahm, Christina C.
AU - Overvad, Kim
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Clavel-Chapelon, Françoise
AU - Boutron-Ruault, Marie Christine
AU - Racine, Antoine
AU - Kaaks, Rudolf
AU - Teucher, Birgit
AU - Boeing, Heiner
AU - Bergmann, Manuela M.
AU - Trichopoulou, Antonia
AU - Trichopoulos, Dimitrios
AU - Lagiou, Pagona
AU - Palli, Domenico
AU - Pala, Valeria
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Siersema, Peter
AU - van Duijnhoven, Franzel
AU - Peeters, Petra H M
AU - Hjartaker, Anette
AU - Engeset, Dagrun
AU - González, Carlos A.
AU - Sánchez, Maria José
AU - Dorronsoro, Miren
AU - Navarro, Carmen
AU - Ardanaz, Eva
AU - Quirós, José R.
AU - Sonestedt, Emily
AU - Ericson, Ulrika
AU - Nilsson, Lena
AU - Palmqvist, Richard
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Key, Timothy J.
AU - Crowe, Francesca L.
AU - Fedirko, Veronika
AU - Wark, Petra A.
AU - Chuang, Shu Chun
AU - Riboli, Elio
PY - 2012/6/22
Y1 - 2012/6/22
N2 - BackgroundEarlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location.Methodology/Principal FindingsAfter a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79–0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals.Conclusions/SignificanceOur results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.
AB - BackgroundEarlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location.Methodology/Principal FindingsAfter a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79–0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals.Conclusions/SignificanceOur results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.
U2 - 10.1371/journal.pone.0039361
DO - 10.1371/journal.pone.0039361
M3 - Article
C2 - 22761771
AN - SCOPUS:84862668532
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e39361
ER -