Diet, lifestyle and risk of K-ras mutation-positive and -negative colorectal adenomas

Petra A. Wark, Wieke Van Der Kuil, Janneke Ploemacher, Goos N P Van Muijen, Chris J J Mulder, Matty P. Weijenberg, Frans J. Kok, Ellen Kampman

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Abstract

    K-ras mutation-positive (K-ras+) and -negative (K-ras -) colorectal adenomas may differ clinically and pathologically. As environmental compounds may cause mutations in the growth-related K-ras oncogene or affect clonal selection depending on mutational status, we evaluated whether the aetiology of K-ras+ and K-ras- adenomas differs. K-ras mutations in codons 12 and 13 were assessed in colorectal adenoma tissue (K-ras+: n = 81, K-ras-: n = 453). Dietary and lifestyle data were collected through questionnaires that were also administered to 709 polyp-free controls. Multiple logistic regression analyses showed that intake of vitamin B2 and monounsaturated fat were differently associated with risk of K-ras+ and K-ras- adenomas; vitamin B2 was inversely associated with K-ras- (highest vs. lowest tertile: odds ratio (OR) = 0.70, 95% confidence interval (CI) = 0.50-0.97, p trend = 0.020), but not with K-ras+ adenomas, and a positive association with monounsaturated fat was confined to K-ras- adenomas (OR = 1.57, 95% CI = 1.06-2.34, p trend = 0.029). Besides, potential, not statistically significant, differences in risk arose because red meat was distinctly positively associated with K-ras+ adenomas (OR = 1.70, 95% CI = 0.94-3.09, p trend = 0.061); total dietary and polyunsaturated fat tended to be inversely associated with risk of K-ras+ but not of K-ras- adenomas; inverse associations with dairy products, calcium, protein and tea were confined to K-ras- adenomas, and smoking was more markedly positively associated with K-ras- adenomas. No differences in risk of K-ras and K-ras - adenomas could be detected for other factors. In conclusion, dietary and lifestyle factors may influence risk of K-ras+ and K-ras- adenomas differently. However, epidemiological literature on diet, lifestyle and colorectal K-ras mutations is inconsistent.

    Original languageEnglish
    Pages (from-to)398-405
    Number of pages8
    JournalInternational Journal of Cancer
    Volume119
    Issue number2
    Early online date28 Feb 2006
    DOIs
    Publication statusPublished - 15 Jul 2006

    Keywords

    • Colorectal adenomatous polyps
    • Diet
    • K-ras
    • Lifestyle
    • Molecular epidemiology

    ASJC Scopus subject areas

    • Cancer Research
    • Oncology

    Fingerprint Dive into the research topics of 'Diet, lifestyle and risk of K-ras mutation-positive and -negative colorectal adenomas'. Together they form a unique fingerprint.

  • Cite this

    Wark, P. A., Van Der Kuil, W., Ploemacher, J., Van Muijen, G. N. P., Mulder, C. J. J., Weijenberg, M. P., ... Kampman, E. (2006). Diet, lifestyle and risk of K-ras mutation-positive and -negative colorectal adenomas. International Journal of Cancer, 119(2), 398-405. https://doi.org/10.1002/ijc.21839