Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: a systematic review

J P Totty, N Bua, A E Harwood, D Carradice, T Wallace, I C Chetter

Research output: Contribution to journalReview article

17 Citations (Scopus)
1 Downloads (Pure)

Abstract

OBJECTIVE: Dialkylcarbomoyl chloride (DACC)-coated dressings (Leukomed Sorbact and Cutimed Sorbact) irreversibly bind bacteria at the wound surface that are then removed when the dressing is changed. They are a recent addition to the wound care professional's armamentarium and have been used in a variety of acute and chronic wounds. This systematic review aims to assess the evidence supporting the use of DACC-coated dressings in the clinical environment.

METHOD: We included all reports of the clinical use of DACC-coated dressings in relation to wound infection. Medline, Embase, CENTRAL and CINAHL databases were searched to September 2016 for studies evaluating the role of DACC-coated dressings in preventing or managing wound infections.

RESULTS: We identified 17 studies with a total of 3408 patients which were included in this review. The DACC-coating was suggested to reduce postoperative surgical site infection rates and result in chronic wounds that subjectively looked cleaner and had less bacterial load on microbiological assessments.

CONCLUSION: Existing evidence for DACC-coated dressings in managing chronic wounds or as a surgical site infection (SSI) prophylaxis is limited but encouraging with evidence in support of DACC-coated dressings preventing and treating infection without adverse effects.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalJournal of wound care
Volume26
Issue number3
DOIs
Publication statusPublished - 2 Mar 2017
Externally publishedYes

Bibliographical note

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Wound Care, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.12968/jowc.2017.26.3.107

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

Keywords

  • Ambulatory Care/methods
  • Anti-Bacterial Agents/administration & dosage
  • Anti-Infective Agents/administration & dosage
  • Bandages
  • Humans
  • Hydrocarbons, Chlorinated/administration & dosage
  • Occlusive Dressings
  • Surgical Wound Infection/prevention & control
  • Wound Healing

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