DHHC palmitoyl transferases: substrate interactions and (patho)physiology

Jennifer Greaves, Luke H Chamberlain

Research output: Contribution to journalReview articlepeer-review

249 Citations (Scopus)


S-palmitoylation is a reversible post-translational modification that occurs on diverse cellular proteins. Palmitoylation can affect proteins in many different ways, including regulating membrane attachment, intracellular trafficking, and membrane micro-localisation. Intracellular palmitoylation reactions are mediated by a family of recently identified aspartate-histidine-histidine-cysteine (DHHC) palmitoyl transferases. More than 20 DHHC proteins are encoded by mammalian genomes, and there is now a major effort to identify DHHC-substrate pairings and to determine how interaction specificity is encoded. Recent studies have highlighted how DHHC proteins regulate cell function and influence physiology and pathophysiology.

Original languageEnglish
Pages (from-to)245-253
Number of pages9
JournalTrends in Biochemical Sciences
Issue number5
Early online date8 Mar 2011
Publication statusPublished - May 2011
Externally publishedYes


  • Acyltransferases
  • Amino Acid Sequence
  • Animals
  • Humans
  • Membrane Proteins
  • Molecular Sequence Data
  • Multigene Family
  • Palmitic Acid
  • Substrate Specificity
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review


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