TY - CHAP
T1 - Deterministic Differential Equations
AU - Lecca, Paola
AU - Re, Angela
AU - Ihekwaba, Adaoha
AU - Mura, Ivan
AU - Nguyen, Thanh-Phuong
PY - 2016
Y1 - 2016
N2 - A practical introduction to the concepts underlying the deterministic modeling of biological systems by coupled differential equations is addressed in this chapter. We present a timed interpretation of the occurrence of events in a biological system that well suits the encoding of qualitative information concerning the structure of networks of interacting components as well as the quantitative information obtained through “wet-laboratory” experiments. We first illustrate the basic rationale of the model specification process, supported by the presentation of a set of increasing complexity examples. We then proceed to describe the possibilities of analytical evaluation of model dynamics as well as the basic concepts underlying the simulative approaches, through application to relevant instances of biological systems.
AB - A practical introduction to the concepts underlying the deterministic modeling of biological systems by coupled differential equations is addressed in this chapter. We present a timed interpretation of the occurrence of events in a biological system that well suits the encoding of qualitative information concerning the structure of networks of interacting components as well as the quantitative information obtained through “wet-laboratory” experiments. We first illustrate the basic rationale of the model specification process, supported by the presentation of a set of increasing complexity examples. We then proceed to describe the possibilities of analytical evaluation of model dynamics as well as the basic concepts underlying the simulative approaches, through application to relevant instances of biological systems.
UR - https://www.mendeley.com/catalogue/8776163d-d1f8-300a-a8d1-775b52a2b615/
UR - https://www.sciencedirect.com/book/9780081000953/computational-systems-biology
U2 - 10.1016/b978-0-08-100095-3.00005-6
DO - 10.1016/b978-0-08-100095-3.00005-6
M3 - Chapter
SN - 978-0-08-100095-3
T3 - Computational Systems Biology
SP - 67
EP - 98
BT - Computational Systems Biology
PB - Elsevier
ER -