Delivering Positive Newborn Screening Results: Cost Analysis of Existing Practice versus Innovative, Co-Designed Strategies from the ReSPoND Study

Francesco Fusco, Jane Chudleigh, Pru Holder, James R. Bonham, Kevin W. Southern, Alan Simpson, Louise Moody, Ellinor K. Olander, Holly Chinnery, Stephen Morris

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Although the communication pathways of Newborn Bloodspot Screening (NBS) are a delicate task, these pathways vary across different conditions and are often not evidence-based. The ReSPoND interventions were co-designed by healthcare professionals alongside parents who had received a positive NBS result for their child. To calculate the cost of these co-designed strategies and the existing communication pathways, we interviewed 71 members of the clinical and laboratory staff of the 13 English NBS laboratories in the English National Health Service. Therefore, a scenario analysis was used to compare the cost of the existing communication pathways to the co-designed strategies delivered by (i) home-visits and (ii) telecommunications. On average, the existing communication pathway cost £447.08 per infant (range: £237.12 to £628.51) or £234,872.75 (£3635.99 to £1,932,986.23) nationally. Implementing the new interventions relying on home-visits exclusively would cost on average £521.62 (£312.84 to £646.39) per infant and £297,816.03 (£4506.37 to £2,550,284.64) nationally, or £447.19 (£235.79 to £552.03) and £231,342.40 (£3923.7 to £1,922,192.22) if implemented via teleconsultations, respectively. The new strategies delivered are not likely to require additional resources compared with current practice. Further research is needed to investigate whether this investment represents good value for money for the NHS budget.
Original languageEnglish
Article number19
Pages (from-to)19
Number of pages9
JournalInternational Journal of Neonatal Screening
Issue number1
Publication statusPublished - 14 Mar 2022

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This project was funded by the National Institute for Health Research Health Services and Delivery Research (NIHR HS&DR) Programme (project number 16/52/25). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Visit the HS&DR website for more information programmes/hsdr/165225/#/ (accessed on 2 March 2022). The funders provided a scientific critique of the proposed study design, methods of data collection and analysis. The Funders and Sponsor were not involved in the interpretation of the data and in writing the manuscript. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • Health services research
  • health economics
  • genetics


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