Dectin-1 is not required for controlling Candida albicans colonization of the gastrointestinal tract

Simon Vautier, Rebecca A. Drummond, Pierre Redelinghuys, Graeme I. Murray, Donna M. MacCallum, Gordon D. Brown

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Candida albicans is normally found as a commensal microbe, commonly colonizing the gastrointestinal tract in humans. However, this fungus can also cause mucosal and systemic infections once immune function is compromised. Dectin-1 is an innate pattern recognition receptor essential for the control of fungal infections in both mice and humans; however, its role in the control of C. albicans colonization of the gastrointestinal tract has not been defined. Here, we demonstrate that in mice dectin-1 is essential for the control of gastrointestinal invasion during systemic infection, with dectin-1 deficiency associating with impaired fungal clearance and dysregulated cytokine production. Surprisingly, however, following oral infection, dectin-1 was not required for the control of mucosal colonization of the gastrointestinal tract, in terms of either fungal burdens or cytokine response. Thus, in mice, dectin-1 is essential for controlling systemic infection with C. albicans but appears to be redundant for the control of gastrointestinal colonization.

Original languageEnglish
Pages (from-to)4216-4222
Number of pages7
JournalInfection and Immunity
Volume80
Issue number12
DOIs
Publication statusPublished - 14 Dec 2012
Externally publishedYes

Fingerprint

Candida albicans
Gastrointestinal Tract
Infection
Cytokines
Pattern Recognition Receptors
Mycoses
Fungi
dectin 1

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Vautier, S., Drummond, R. A., Redelinghuys, P., Murray, G. I., MacCallum, D. M., & Brown, G. D. (2012). Dectin-1 is not required for controlling Candida albicans colonization of the gastrointestinal tract. Infection and Immunity, 80(12), 4216-4222. https://doi.org/10.1128/IAI.00559-12

Dectin-1 is not required for controlling Candida albicans colonization of the gastrointestinal tract. / Vautier, Simon; Drummond, Rebecca A.; Redelinghuys, Pierre; Murray, Graeme I.; MacCallum, Donna M.; Brown, Gordon D.

In: Infection and Immunity, Vol. 80, No. 12, 14.12.2012, p. 4216-4222.

Research output: Contribution to journalArticle

Vautier, S, Drummond, RA, Redelinghuys, P, Murray, GI, MacCallum, DM & Brown, GD 2012, 'Dectin-1 is not required for controlling Candida albicans colonization of the gastrointestinal tract' Infection and Immunity, vol. 80, no. 12, pp. 4216-4222. https://doi.org/10.1128/IAI.00559-12
Vautier, Simon ; Drummond, Rebecca A. ; Redelinghuys, Pierre ; Murray, Graeme I. ; MacCallum, Donna M. ; Brown, Gordon D. / Dectin-1 is not required for controlling Candida albicans colonization of the gastrointestinal tract. In: Infection and Immunity. 2012 ; Vol. 80, No. 12. pp. 4216-4222.
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