COVID-19 is associated with cardiac structural and functional remodelling in healthy middle-aged and older individuals

Mushidur Rahman; Sophie L Russell; Nduka C Okwose; Gordon McGregor; Helen Maddock; Prithwish Banerjee; Djordje G Jakovljevic

doi:10.1111/cpf.12909

COVID-19 is associated with cardiac structural and functional remodelling in healthy middle-aged and older individuals

Mushidur Rahman
, Sophie L Russell
, Nduka C Okwose
, Gordon McGregor
, Helen Maddock
, Prithwish Banerjee
, Djordje G Jakovljevic

University Hospitals Coventry and Warwickshire NHS Trust

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

76 Downloads (Pure)

Abstract

Background: Coronavirus disease 2019 (COVID-19) was declared a global pandemic in 2019. It remains uncertain to what extent COVID-19 effects the heart in healthy individuals. To evaluate the effect of the COVID-19 on cardiac structure and function in middle-aged and older individuals.

Methods: A single-centre prospective observational study enroled a total of 124 participants (84 with history of COVID-19 [COVID-19 group] and 40 without a history of COVID-19 [non-COVID group]). All participants underwent echocardiography with speckle tracking to assess cardiac structure and function at rest and during peak exercise.

Results: There were no differences in left and right ventricular diastolic function (p ≥ 0.05) between the COVID-19 and non-COVID-19 groups. Participants in COVID-19 group demonstrated higher left ventricular mass (130 ± 39.8 vs. 113 ± 27.2 g, p = 0.008) and relative wall thickness (0.38 ± 0.07 vs. 0.36 ± 0.13, p = 0.049). Left ventricular global longitudinal strain was reduced in the COVID-19 group at rest and at peak-exercise (rest: 18.3 ± 2.01 vs. 19.3 ± 1.53%, p = 0.004; peak exercise: 19.1 ± 2.20 vs. 21.0 ± 1.58%, p ≤ 0.001). However, no difference was seen in resting left ventricular ejection fraction (58 ± 2.89 vs. 59 ± 2.51%, p = 0.565) between groups. Right ventricular fractional area change was reduced in the COVID-19 group (p = 0.012).

Conclusion: Cardiac structural and functional remodelling was observed in middle-aged and older otherwise healthy individuals with a history of COVID-19.

Original language	English
Article number	e12909
Pages (from-to)	(In-Press)
Number of pages	12
Journal	Clinical Physiology and Functional Imaging
Volume	45
Issue number	1
Early online date	8 Oct 2024
DOIs	https://doi.org/10.1111/cpf.12909
Publication status	Published - Jan 2025

Bibliographical note

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Funder

The study was supported by Coventry University COVID‐19 Research and Innovation fund for the PhD Studentship developed by Professor Djordje Jakovljevic and awarded to Mushidur Rahman.

Funding

The study was supported by Coventry University COVID‐19 Research and Innovation fund for the PhD Studentship developed by Professor Djordje Jakovljevic and awarded to Mushidur Rahman.

Funders
Coventry University

Keywords

cardiac structure and function
COVID‐19
speckle tracking echocardiography

Access to Document

10.1111/cpf.12909Licence: CC BY

McGregor2024VoRFinal published version, 2.19 MBLicence: CC BY

Cite this

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title = "COVID-19 is associated with cardiac structural and functional remodelling in healthy middle-aged and older individuals",

abstract = "Background: Coronavirus disease 2019 (COVID-19) was declared a global pandemic in 2019. It remains uncertain to what extent COVID-19 effects the heart in healthy individuals. To evaluate the effect of the COVID-19 on cardiac structure and function in middle-aged and older individuals. Methods: A single-centre prospective observational study enroled a total of 124 participants (84 with history of COVID-19 [COVID-19 group] and 40 without a history of COVID-19 [non-COVID group]). All participants underwent echocardiography with speckle tracking to assess cardiac structure and function at rest and during peak exercise. Results: There were no differences in left and right ventricular diastolic function (p ≥ 0.05) between the COVID-19 and non-COVID-19 groups. Participants in COVID-19 group demonstrated higher left ventricular mass (130 ± 39.8 vs. 113 ± 27.2 g, p = 0.008) and relative wall thickness (0.38 ± 0.07 vs. 0.36 ± 0.13, p = 0.049). Left ventricular global longitudinal strain was reduced in the COVID-19 group at rest and at peak-exercise (rest: 18.3 ± 2.01 vs. 19.3 ± 1.53\%, p = 0.004; peak exercise: 19.1 ± 2.20 vs. 21.0 ± 1.58\%, p ≤ 0.001). However, no difference was seen in resting left ventricular ejection fraction (58 ± 2.89 vs. 59 ± 2.51\%, p = 0.565) between groups. Right ventricular fractional area change was reduced in the COVID-19 group (p = 0.012). Conclusion: Cardiac structural and functional remodelling was observed in middle-aged and older otherwise healthy individuals with a history of COVID-19.",

keywords = "cardiac structure and function, COVID‐19, speckle tracking echocardiography",

author = "Mushidur Rahman and Russell, \{Sophie L\} and Okwose, \{Nduka C\} and Gordon McGregor and Helen Maddock and Prithwish Banerjee and Jakovljevic, \{Djordje G\}",

note = "This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.",

year = "2025",

month = jan,

doi = "10.1111/cpf.12909",

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T1 - COVID-19 is associated with cardiac structural and functional remodelling in healthy middle-aged and older individuals

AU - Rahman, Mushidur

AU - Russell, Sophie L

AU - Okwose, Nduka C

AU - McGregor, Gordon

AU - Maddock, Helen

AU - Banerjee, Prithwish

AU - Jakovljevic, Djordje G

N1 - This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PY - 2025/1

Y1 - 2025/1

N2 - Background: Coronavirus disease 2019 (COVID-19) was declared a global pandemic in 2019. It remains uncertain to what extent COVID-19 effects the heart in healthy individuals. To evaluate the effect of the COVID-19 on cardiac structure and function in middle-aged and older individuals. Methods: A single-centre prospective observational study enroled a total of 124 participants (84 with history of COVID-19 [COVID-19 group] and 40 without a history of COVID-19 [non-COVID group]). All participants underwent echocardiography with speckle tracking to assess cardiac structure and function at rest and during peak exercise. Results: There were no differences in left and right ventricular diastolic function (p ≥ 0.05) between the COVID-19 and non-COVID-19 groups. Participants in COVID-19 group demonstrated higher left ventricular mass (130 ± 39.8 vs. 113 ± 27.2 g, p = 0.008) and relative wall thickness (0.38 ± 0.07 vs. 0.36 ± 0.13, p = 0.049). Left ventricular global longitudinal strain was reduced in the COVID-19 group at rest and at peak-exercise (rest: 18.3 ± 2.01 vs. 19.3 ± 1.53%, p = 0.004; peak exercise: 19.1 ± 2.20 vs. 21.0 ± 1.58%, p ≤ 0.001). However, no difference was seen in resting left ventricular ejection fraction (58 ± 2.89 vs. 59 ± 2.51%, p = 0.565) between groups. Right ventricular fractional area change was reduced in the COVID-19 group (p = 0.012). Conclusion: Cardiac structural and functional remodelling was observed in middle-aged and older otherwise healthy individuals with a history of COVID-19.

AB - Background: Coronavirus disease 2019 (COVID-19) was declared a global pandemic in 2019. It remains uncertain to what extent COVID-19 effects the heart in healthy individuals. To evaluate the effect of the COVID-19 on cardiac structure and function in middle-aged and older individuals. Methods: A single-centre prospective observational study enroled a total of 124 participants (84 with history of COVID-19 [COVID-19 group] and 40 without a history of COVID-19 [non-COVID group]). All participants underwent echocardiography with speckle tracking to assess cardiac structure and function at rest and during peak exercise. Results: There were no differences in left and right ventricular diastolic function (p ≥ 0.05) between the COVID-19 and non-COVID-19 groups. Participants in COVID-19 group demonstrated higher left ventricular mass (130 ± 39.8 vs. 113 ± 27.2 g, p = 0.008) and relative wall thickness (0.38 ± 0.07 vs. 0.36 ± 0.13, p = 0.049). Left ventricular global longitudinal strain was reduced in the COVID-19 group at rest and at peak-exercise (rest: 18.3 ± 2.01 vs. 19.3 ± 1.53%, p = 0.004; peak exercise: 19.1 ± 2.20 vs. 21.0 ± 1.58%, p ≤ 0.001). However, no difference was seen in resting left ventricular ejection fraction (58 ± 2.89 vs. 59 ± 2.51%, p = 0.565) between groups. Right ventricular fractional area change was reduced in the COVID-19 group (p = 0.012). Conclusion: Cardiac structural and functional remodelling was observed in middle-aged and older otherwise healthy individuals with a history of COVID-19.

KW - cardiac structure and function

KW - COVID‐19

KW - speckle tracking echocardiography

UR - https://www.scopus.com/pages/publications/85205900832

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DO - 10.1111/cpf.12909

M3 - Article

C2 - 39377164

SN - 1475-0961

VL - 45

SP - (In-Press)

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 1

M1 - e12909

ER -

COVID-19 is associated with cardiac structural and functional remodelling in healthy middle-aged and older individuals

Abstract

Bibliographical note

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Funding

Keywords

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