Comparison of the critical concentration and critical volume hypotheses to model non-specific toxicity of individual compounds

M. St J. Warne, D. W. Connell, D. W. Hawker

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The critical concentration and critical volume hypotheses for non-specific toxicity require the molar concentration (CC) and volume fraction (VF) of toxicant in target tissue to be constant. Thus these factors should be independent of the octanol-water partition coefficient (Kow) for individual compounds. CC and VF values were calculated based on acute sub-lethal, acute and chronic lethal toxicity data, Kow and pure component molar volume (MV) data. When these values were plotted against log Kow, the slopes of the regression equations were significantly different to zero but were not significantly different from each other. The observed slight increase in CC and VF with increasing log Kow was attributed predominantly, to the use of Kow values which overestimate the target tissue-water partition coefficient (Kttw. An additional error associated with the volume fraction calculations was the use of the molar volume instead of partial molar volume. VF and CC values were calculated correcting for both these factors and regressed against log Kow. The resulting for VF had a gradient not significantly different from zero, while that for CC was, thus indicating the superiority of the critical volume hypothesis in modelling non-specific toxicity of individual compounds.

Original languageEnglish
Pages (from-to)187-195
Number of pages9
JournalToxicology
Volume66
Issue number2
DOIs
Publication statusPublished - 25 Feb 1991
Externally publishedYes

Fingerprint

Toxicity
Volume fraction
Octanols
Water
Density (specific gravity)
Tissue

Keywords

  • Critical concentration
  • Narcosis
  • Partial molar volume
  • Partition coefficients
  • Volume fraction

ASJC Scopus subject areas

  • Toxicology

Cite this

Comparison of the critical concentration and critical volume hypotheses to model non-specific toxicity of individual compounds. / Warne, M. St J.; Connell, D. W.; Hawker, D. W.

In: Toxicology, Vol. 66, No. 2, 25.02.1991, p. 187-195.

Research output: Contribution to journalArticle

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