Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells

Hamed Rezaie, Reza Alipanah-Moghadam, Farhad Jeddi, Cain C. T. Clark, Vahideh Aghamohammadi, Ali Nemati

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Breast cancer is one of the most prevalent and deadly cancers among women worldwide. Recently, natural compounds have been widely used for the treatment of breast cancer. Present study evaluated antiproliferative and anti-metastasis activities of two natural compounds of dandelion and all-trans-retinoic acid (ATRA) in human MCF-7 and MDA-MB231 breast cancer cells. We also evaluated the expression of MMP-2, MMP-9, IL-1β, p53, NM23 and KAI1 genes. Data showed a clear additive cytotoxic effect in concentrations of 40 μM ATRA with 1.5 and 4 mg/ml of dandelion extract in MCF-7 and MDA-MB231 cells, respectively. In both cell lines, compared with the untreated cells, the expression levels of MMP-9 and IL-1β were significantly decreased while p53 and KAI1 expression levels were increased. Besides, MMP-2 and NM23 had different expressions in the two studied cell lines. In conclusion, dandelion/ATRA co-treatment, in addition to having strong cytotoxic effects, has putative effects on the expression of anti-metastatic genes in both breast cancer cells.
Original languageEnglish
Article number15074
Number of pages12
JournalScientific Reports
Issue number1
Early online date12 Sept 2023
Publication statusE-pub ahead of print - 12 Sept 2023

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This study is financially supported by the Ardabil university of medical sciences.


  • Cancer
  • Diseases
  • Medical research
  • Molecular medicine
  • Oncology


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