Circulating levels of adropin and overweight/obesity: a systematic review and meta-analysis of observational studies

Sepideh Soltani, Roya Kolahdouz-Mohammadi, Suleyman Aydin, Somaye Yosaee, Cain C.T. Clark, Shima Abdollahi

    Research output: Contribution to journalReview articlepeer-review

    4 Citations (Scopus)

    Abstract

    The association between circulating adropin levels and overweight/obesity is currently unclear. The aim of this study was thus to investigate and seek to determine the association between circulating adropin levels and overweight/obesity using the meta-analysis approach of observational studies. A comprehensive literature search was carried out through the PubMed, Web of Science, and SCOPUS databases to identify relevant observational studies that assessed the relationship between circulating adropin levels and overweight/obesity up to September 2020. A random-effects model was used to compute the pooled weighted mean difference (WMD) with 95% confidence intervals (CI). The meta-analysis of five studies (n = 643 participants) showed that circulating adropin levels were significantly lower in the overweight/obese vs. the normal-weight participants (WMD = − 0.96 ng/ml, 95% CI = − 1.72 to − 0.19, P = 0.01; I2 = 88.4%). In subgroup analyses, lower circulating adropin levels in obese participants compared with normal-weight were observed in Asians (WMD = − 1.58 ng/ml, 95% CI = − 1.96 to − 1.21, P < 0.001; I2 = 0.00%), and in patients with metabolic disorders (WMD = − 1.26 ng/ml, 95% CI = − 1.76 to − 0.77, P < 0.001; I2 = 44.6%), respectively. Circulating adropin levels were significantly lower in overweight/obese vs. normal-weight participants, suggesting a possible role of this hormone in the development of obesity. However, the present research indicates that further studies are needed to conclusively confirm whether adropin is a viable marker of obesity.

    Original languageEnglish
    Pages (from-to)15-22
    Number of pages8
    JournalHormones
    Volume21
    Issue number1
    Early online date13 Dec 2021
    DOIs
    Publication statusPublished - Mar 2022

    Bibliographical note

    Funding Information:
    This work was funded by the Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

    Publisher Copyright:
    © 2021, Hellenic Endocrine Society.

    Keywords

    • Adropin
    • Meta-analysis
    • Obesity
    • Observational studies
    • Overweight

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism

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