Abstract
Chikungunya virus (CHIKV) was until recently perceived only as a tropical disease. Since the first report of a case in Saint Martin Island in 2013, it has spread to South, Central, and North America. The first local transmission in the continental United States was reported in Florida in July 2014. CHIV infection is known to cause debilitating rheumatologic disease. Older adults are particularly susceptible to severe and chronic infection. Without an effective vaccine and antiviral therapy to prevent and control CHIKV, U.S. geriatricians could soon be confronted with major clinical, functional, and therapeutic challenges. After a general overview of CHIKV infection, this review will examine reasons why it has become such a threat to the United States and consider factors that contribute to the greater burden and effect of this disease in elderly adults. Consideration will be given to how aging and immunosenescence may contribute to CHIKV's atypical and more-severe clinical features in older adults. This review concludes with possible therapeutic approaches that best fit the unique needs of older adults, especially with regard to multimorbidity and polypharmacy.
| Original language | English |
|---|---|
| Pages (from-to) | 2529-2534 |
| Number of pages | 6 |
| Journal | Journal of the American Geriatrics Society |
| Volume | 65 |
| Issue number | 11 |
| Early online date | 21 Sep 2017 |
| DOIs | |
| Publication status | Published - 1 Nov 2017 |
| Externally published | Yes |
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Keywords
- aged people
- chikungunya virus infection
- clinical forms
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
Chikungunya Virus Infection : Why Should U.S. Geriatricians Be Aware of It? / Lang, Pierre Olivier; Loulergue, Pierre; Aspinall, Richard.
In: Journal of the American Geriatrics Society, Vol. 65, No. 11, 01.11.2017, p. 2529-2534.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chikungunya Virus Infection
T2 - Why Should U.S. Geriatricians Be Aware of It?
AU - Lang, Pierre Olivier
AU - Loulergue, Pierre
AU - Aspinall, Richard
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Chikungunya virus (CHIKV) was until recently perceived only as a tropical disease. Since the first report of a case in Saint Martin Island in 2013, it has spread to South, Central, and North America. The first local transmission in the continental United States was reported in Florida in July 2014. CHIV infection is known to cause debilitating rheumatologic disease. Older adults are particularly susceptible to severe and chronic infection. Without an effective vaccine and antiviral therapy to prevent and control CHIKV, U.S. geriatricians could soon be confronted with major clinical, functional, and therapeutic challenges. After a general overview of CHIKV infection, this review will examine reasons why it has become such a threat to the United States and consider factors that contribute to the greater burden and effect of this disease in elderly adults. Consideration will be given to how aging and immunosenescence may contribute to CHIKV's atypical and more-severe clinical features in older adults. This review concludes with possible therapeutic approaches that best fit the unique needs of older adults, especially with regard to multimorbidity and polypharmacy.
AB - Chikungunya virus (CHIKV) was until recently perceived only as a tropical disease. Since the first report of a case in Saint Martin Island in 2013, it has spread to South, Central, and North America. The first local transmission in the continental United States was reported in Florida in July 2014. CHIV infection is known to cause debilitating rheumatologic disease. Older adults are particularly susceptible to severe and chronic infection. Without an effective vaccine and antiviral therapy to prevent and control CHIKV, U.S. geriatricians could soon be confronted with major clinical, functional, and therapeutic challenges. After a general overview of CHIKV infection, this review will examine reasons why it has become such a threat to the United States and consider factors that contribute to the greater burden and effect of this disease in elderly adults. Consideration will be given to how aging and immunosenescence may contribute to CHIKV's atypical and more-severe clinical features in older adults. This review concludes with possible therapeutic approaches that best fit the unique needs of older adults, especially with regard to multimorbidity and polypharmacy.
KW - aged people
KW - chikungunya virus infection
KW - clinical forms
UR - http://www.scopus.com/inward/record.url?scp=85032221067&partnerID=8YFLogxK
U2 - 10.1111/jgs.15104
DO - 10.1111/jgs.15104
M3 - Article
VL - 65
SP - 2529
EP - 2534
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
SN - 0002-8614
IS - 11
ER -