Chemoprophylaxis of Theileria annulata and Theileria parva infections of calves with buparvaquone

G. M. Wilkie, C. G.D. Brown, E. Kirvar, M. Thomas, S. M. Williamson, L. J. Bell-Sakyi, O. Sparagano

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A clinical trial testing the prophylactic effect of a 5 mg kg-1 dose of buparvaquone on either Theileria annulata or Theileria parva experimental infections of calves demonstrated its efficacy for periods of at least seven days. The drug given 1 h or seven days before 50% lethal T. annulata sporozoite infection protected all eight calves, but prophylaxis was insufficient after 14 days to protect two out of four calves from severe reaction. When immunity was challenged by a lethal second parasite dose a month after the first, all these calves were immune. In the T. parva trial, calves given drug 1 h or seven days before a 25% lethal infection underwent minimal reactions, but some were over-protected and were susceptible to a similar challenge sporozoite dose. Although drug levels remaining 14 days after prophylaxis protected these calves from the mild challenge, some parameters measured were within the range of the 'no drug' control group. These results indicate the effectiveness of a single 5 mg kg-1 dose of buparvaquone for more than seven days but also the potential risk of its use in the infection and treatment method of immunisation. It is suggested that there may be circumstances where simple field prophylactic treatment with buparvaquone may be beneficial.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalVeterinary Parasitology
Volume78
Issue number1
DOIs
Publication statusPublished - 17 Jul 1998
Externally publishedYes

Fingerprint

buparvaquone
Theileria annulata
Theileria parva
chemoprevention
Chemoprevention
calves
Sporozoites
Infection
infection
drugs
sporozoites
Pharmaceutical Preparations
dosage
Drug and Narcotic Control
disease control
Immunity
Immunization
Parasites
Clinical Trials
Control Groups

Keywords

  • Buparvaquone
  • Cattle-Protozoa
  • Control methods-Protozoa
  • Theileria spp

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)

Cite this

Wilkie, G. M., Brown, C. G. D., Kirvar, E., Thomas, M., Williamson, S. M., Bell-Sakyi, L. J., & Sparagano, O. (1998). Chemoprophylaxis of Theileria annulata and Theileria parva infections of calves with buparvaquone. Veterinary Parasitology, 78(1), 1-12. https://doi.org/10.1016/S0304-4017(98)00126-5

Chemoprophylaxis of Theileria annulata and Theileria parva infections of calves with buparvaquone. / Wilkie, G. M.; Brown, C. G.D.; Kirvar, E.; Thomas, M.; Williamson, S. M.; Bell-Sakyi, L. J.; Sparagano, O.

In: Veterinary Parasitology, Vol. 78, No. 1, 17.07.1998, p. 1-12.

Research output: Contribution to journalArticle

Wilkie, GM, Brown, CGD, Kirvar, E, Thomas, M, Williamson, SM, Bell-Sakyi, LJ & Sparagano, O 1998, 'Chemoprophylaxis of Theileria annulata and Theileria parva infections of calves with buparvaquone' Veterinary Parasitology, vol. 78, no. 1, pp. 1-12. https://doi.org/10.1016/S0304-4017(98)00126-5
Wilkie, G. M. ; Brown, C. G.D. ; Kirvar, E. ; Thomas, M. ; Williamson, S. M. ; Bell-Sakyi, L. J. ; Sparagano, O. / Chemoprophylaxis of Theileria annulata and Theileria parva infections of calves with buparvaquone. In: Veterinary Parasitology. 1998 ; Vol. 78, No. 1. pp. 1-12.
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