Characterisation of brain D2 dopamine receptors solubilised by lysophosphatidylcholine

Mark Wheatley; Philip G. Strange

doi:10.1016/0014-5793(83)80351-2

Characterisation of brain D₂ dopamine receptors solubilised by lysophosphatidylcholine

Mark Wheatley
, Philip G. Strange

Queen's Medical Centre

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Brain D₂ dopamine receptors have been solubilised using lysophosphatidylcholine. The inclusion of proteinase inhibitors during solubilisation enables a preparation to be obtained containing a high proportion of solubilised D₂ receptors with pharmacological properties similar to those of membrane bound D₂ receptors.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	FEBS Letters
Volume	151
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(83)80351-2
Publication status	Published - 10 Jan 1983
Externally published	Yes

Bibliographical note

Free access

Keywords

D dopamine receptor
Lysophosphatidylcholine [H]Spiperone Bovine caudate nucleus
Solubilisation

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/0014-5793(83)80351-2

Cite this

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abstract = "Brain D2 dopamine receptors have been solubilised using lysophosphatidylcholine. The inclusion of proteinase inhibitors during solubilisation enables a preparation to be obtained containing a high proportion of solubilised D2 receptors with pharmacological properties similar to those of membrane bound D2 receptors.",

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