Cerebral Hemodynamics Underlying Artery-to-Artery Embolism in Symptomatic Intracranial Atherosclerotic Disease

Xueyan Feng, Hui Fang, Bonaventure Y M Ip, Ka Lung Chan, Shuang Li, Xuan Tian, Lina Zheng, Yuying Liu, Linfang Lan, Haipeng Liu, Jill Abrigo, Sze Ho Ma, Florence S Y Fan, Vincent H L Ip, Yannie O Y Soo, Vincent C T Mok, Bo Song, Thomas W Leung, Yuming Xu, Xinyi Leng

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    2 Citations (Scopus)

    Abstract

    Artery-to-artery embolism (AAE) is a common stroke mechanism in intracranial atherosclerotic disease (ICAD), associated with a considerable risk of recurrent stroke. We aimed to investigate cerebral hemodynamic features associated with AAE in symptomatic ICAD. Patients with anterior-circulation, symptomatic ICAD confirmed in CT angiography (CTA) were recruited. We classified probable stroke mechanisms as isolated parent artery atherosclerosis occluding penetrating artery, AAE, hypoperfusion, and mixed mechanisms, largely based on infarct topography. CTA-based computational fluid dynamics (CFD) models were built to simulate blood flow across culprit ICAD lesions. Translesional pressure ratio (PR = Pressure /Pressure ) and wall shear stress ratio (WSSR = WSS /WSS ) were calculated, to reflect the relative, translesional changes of the two hemodynamic metrics. Low PR (PR ≤ median) and high WSSR (WSSR ≥ 4th quartile) respectively indicated large translesional pressure and elevated WSS upon the lesion. Among 99 symptomatic ICAD patients, 44 had AAE as a probable stroke mechanism, 13 with AAE alone and 31 with coexisting hypoperfusion. High WSSR was independently associated with AAE (adjusted OR = 3.90; P = 0.022) in multivariate logistic regression. There was significant WSSR-PR interaction on the presence of AAE (P for interaction = 0.013): high WSSR was more likely to associate with AAE in those with low PR (P = 0.075), but not in those with normal PR (P = 0.959). Excessively elevated WSS in ICAD might increase the risk of AAE. Such association was more prominent in those with large translesional pressure gradient. Hypoperfusion, commonly coexisting with AAE, might be a therapeutic indicator for secondary stroke prevention in symptomatic ICAD with AAE. [Abstract copyright: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.]
    Original languageEnglish
    Pages (from-to)(In-Press)
    JournalTranslational Stroke Research
    Volume(In-Press)
    Early online date10 Mar 2023
    DOIs
    Publication statusE-pub ahead of print - 10 Mar 2023

    Funder

    This study was funded by the General Research Fund (Reference No. 14106019 & 14138416), Hong Kong Research Grants Council; Health and Medical Research Fund (Reference No. 07180366), Hong Kong Food and Health Bureau; the NHC Key Laboratory of Prevention and treatment of Cerebrovascular Disease, Henan Key Laboratory of Cerebrovascular Diseases (Zhengzhou University), the Non-profit Central Research Institute and Major Science to Yuming Xu (Grant No. 2020-PT310-01).

    Keywords

    • Stroke
    • Intracranial Atherosclerosis
    • Prognosis
    • Embolism
    • Hemodynamics

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