Cardiovascular adaptation in people with multiple sclerosis following a 12 week exercise programme suggest deconditioning rather than autonomic dysfunction caused by the disease

Martyn Morris, M.G. Feltham, J. Collett, H. Izadi, D.T. Wade, A.J. Meaney, K. Howells, C. Sackley, H. Dawes

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Guidelines for optimal exercise doses in people with multiple sclerosis (MS) have to be established. We need to ascertain the basic physiological and perceptual response and adaptation to different exercise doses in this clinical population.                                                                                                                                                 AIM: The aim of this paper was to explore the response during maximal and sub-maximal exercise in people with MS prior to and following two different twelve week exercise programmes.                                                                                                                                                                                                                                                           DESIGN: Sub-analysis of per protocol exercise data of a two group, single blinded, randomised control trial.                                                                                             SETTING: Multicentre (community leisure and rehabilitation centres).                                                                                                                                                             POPULATION: Participants with MS assigned to a continuous (N.=12; mean±SE age=52.3±2.08; Barthel index median & range=19&13-20) or interval (N.=9; mean±SE age=49.3±3.5; Barthel index median & range=19&18-20) exercise programme.                                                                                                                                               METHODS: Cardiovascular, respiratory and perceptual exercise response and adaption was measured at maximal and sub-maximal levels of physical exercise prior to and following a twelve week exercise programme, delivered at different intensities.                                                                                                                                                     RESULTS: Irrespective of the type of exercise programme followed, there was a significant increase in peak power (z=-1.98; P=0.05) and normalised oxygen uptake during unloaded cycling (z =-2.00; P=0.05). At discharge from the exercise programmes, the cardiovascular response to sub-maximal exercise had significantly changed (t(360) =-4.62; p<0.01).                                                                                                                                                                                                                                           CONCLUSION: The response in people with MS at maximal and sub-maximal levels of physical exercise following a twelve week programme is analogous to non-diseased adults.                                                                                                                                                                                                                                                         CLINICAL REHABILITATION IMPACT: Cardiovascular adaptation in people with MS following a twelve week exercise programme suggests deconditioning rather than autonomic dysfunction caused by the disease.
Original languageEnglish
Pages (from-to)765-774
Number of pages10
Journal-
Volume49
Issue number6
Publication statusPublished - 2013

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Multiple Sclerosis
Exercise
Rehabilitation Centers
Leisure Activities
Guidelines
Oxygen
Population

Keywords

  • Multiple sclerosis
  • Exercise
  • Adaption, physiological
  • Cardiovascular deconditioning

Cite this

Morris, M., Feltham, M. G., Collett, J., Izadi, H., Wade, D. T., Meaney, A. J., ... Dawes, H. (2013). Cardiovascular adaptation in people with multiple sclerosis following a 12 week exercise programme suggest deconditioning rather than autonomic dysfunction caused by the disease. -, 49(6), 765-774.

Cardiovascular adaptation in people with multiple sclerosis following a 12 week exercise programme suggest deconditioning rather than autonomic dysfunction caused by the disease. / Morris, Martyn; Feltham, M.G.; Collett, J.; Izadi, H.; Wade, D.T.; Meaney, A.J.; Howells, K.; Sackley, C.; Dawes, H.

In: -, Vol. 49, No. 6, 2013, p. 765-774.

Research output: Contribution to journalArticle

Morris, M, Feltham, MG, Collett, J, Izadi, H, Wade, DT, Meaney, AJ, Howells, K, Sackley, C & Dawes, H 2013, 'Cardiovascular adaptation in people with multiple sclerosis following a 12 week exercise programme suggest deconditioning rather than autonomic dysfunction caused by the disease' -, vol. 49, no. 6, pp. 765-774.
Morris, Martyn ; Feltham, M.G. ; Collett, J. ; Izadi, H. ; Wade, D.T. ; Meaney, A.J. ; Howells, K. ; Sackley, C. ; Dawes, H. / Cardiovascular adaptation in people with multiple sclerosis following a 12 week exercise programme suggest deconditioning rather than autonomic dysfunction caused by the disease. In: -. 2013 ; Vol. 49, No. 6. pp. 765-774.
@article{ba90978e6561488b94a9841f0683cf03,
title = "Cardiovascular adaptation in people with multiple sclerosis following a 12 week exercise programme suggest deconditioning rather than autonomic dysfunction caused by the disease",
abstract = "BACKGROUND: Guidelines for optimal exercise doses in people with multiple sclerosis (MS) have to be established. We need to ascertain the basic physiological and perceptual response and adaptation to different exercise doses in this clinical population.                                                                                                                                                 AIM: The aim of this paper was to explore the response during maximal and sub-maximal exercise in people with MS prior to and following two different twelve week exercise programmes.                                                                                                                                                                                                                                                           DESIGN: Sub-analysis of per protocol exercise data of a two group, single blinded, randomised control trial.                                                                                             SETTING: Multicentre (community leisure and rehabilitation centres).                                                                                                                                                             POPULATION: Participants with MS assigned to a continuous (N.=12; mean±SE age=52.3±2.08; Barthel index median & range=19&13-20) or interval (N.=9; mean±SE age=49.3±3.5; Barthel index median & range=19&18-20) exercise programme.                                                                                                                                               METHODS: Cardiovascular, respiratory and perceptual exercise response and adaption was measured at maximal and sub-maximal levels of physical exercise prior to and following a twelve week exercise programme, delivered at different intensities.                                                                                                                                                     RESULTS: Irrespective of the type of exercise programme followed, there was a significant increase in peak power (z=-1.98; P=0.05) and normalised oxygen uptake during unloaded cycling (z =-2.00; P=0.05). At discharge from the exercise programmes, the cardiovascular response to sub-maximal exercise had significantly changed (t(360) =-4.62; p<0.01).                                                                                                                                                                                                                                           CONCLUSION: The response in people with MS at maximal and sub-maximal levels of physical exercise following a twelve week programme is analogous to non-diseased adults.                                                                                                                                                                                                                                                         CLINICAL REHABILITATION IMPACT: Cardiovascular adaptation in people with MS following a twelve week exercise programme suggests deconditioning rather than autonomic dysfunction caused by the disease.",
keywords = "Multiple sclerosis, Exercise, Adaption, physiological, Cardiovascular deconditioning",
author = "Martyn Morris and M.G. Feltham and J. Collett and H. Izadi and D.T. Wade and A.J. Meaney and K. Howells and C. Sackley and H. Dawes",
year = "2013",
language = "English",
volume = "49",
pages = "765--774",
journal = "Annals of Physical and Rehabilitation Medicine",
issn = "1877-0657",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Cardiovascular adaptation in people with multiple sclerosis following a 12 week exercise programme suggest deconditioning rather than autonomic dysfunction caused by the disease

AU - Morris, Martyn

AU - Feltham, M.G.

AU - Collett, J.

AU - Izadi, H.

AU - Wade, D.T.

AU - Meaney, A.J.

AU - Howells, K.

AU - Sackley, C.

AU - Dawes, H.

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Guidelines for optimal exercise doses in people with multiple sclerosis (MS) have to be established. We need to ascertain the basic physiological and perceptual response and adaptation to different exercise doses in this clinical population.                                                                                                                                                 AIM: The aim of this paper was to explore the response during maximal and sub-maximal exercise in people with MS prior to and following two different twelve week exercise programmes.                                                                                                                                                                                                                                                           DESIGN: Sub-analysis of per protocol exercise data of a two group, single blinded, randomised control trial.                                                                                             SETTING: Multicentre (community leisure and rehabilitation centres).                                                                                                                                                             POPULATION: Participants with MS assigned to a continuous (N.=12; mean±SE age=52.3±2.08; Barthel index median & range=19&13-20) or interval (N.=9; mean±SE age=49.3±3.5; Barthel index median & range=19&18-20) exercise programme.                                                                                                                                               METHODS: Cardiovascular, respiratory and perceptual exercise response and adaption was measured at maximal and sub-maximal levels of physical exercise prior to and following a twelve week exercise programme, delivered at different intensities.                                                                                                                                                     RESULTS: Irrespective of the type of exercise programme followed, there was a significant increase in peak power (z=-1.98; P=0.05) and normalised oxygen uptake during unloaded cycling (z =-2.00; P=0.05). At discharge from the exercise programmes, the cardiovascular response to sub-maximal exercise had significantly changed (t(360) =-4.62; p<0.01).                                                                                                                                                                                                                                           CONCLUSION: The response in people with MS at maximal and sub-maximal levels of physical exercise following a twelve week programme is analogous to non-diseased adults.                                                                                                                                                                                                                                                         CLINICAL REHABILITATION IMPACT: Cardiovascular adaptation in people with MS following a twelve week exercise programme suggests deconditioning rather than autonomic dysfunction caused by the disease.

AB - BACKGROUND: Guidelines for optimal exercise doses in people with multiple sclerosis (MS) have to be established. We need to ascertain the basic physiological and perceptual response and adaptation to different exercise doses in this clinical population.                                                                                                                                                 AIM: The aim of this paper was to explore the response during maximal and sub-maximal exercise in people with MS prior to and following two different twelve week exercise programmes.                                                                                                                                                                                                                                                           DESIGN: Sub-analysis of per protocol exercise data of a two group, single blinded, randomised control trial.                                                                                             SETTING: Multicentre (community leisure and rehabilitation centres).                                                                                                                                                             POPULATION: Participants with MS assigned to a continuous (N.=12; mean±SE age=52.3±2.08; Barthel index median & range=19&13-20) or interval (N.=9; mean±SE age=49.3±3.5; Barthel index median & range=19&18-20) exercise programme.                                                                                                                                               METHODS: Cardiovascular, respiratory and perceptual exercise response and adaption was measured at maximal and sub-maximal levels of physical exercise prior to and following a twelve week exercise programme, delivered at different intensities.                                                                                                                                                     RESULTS: Irrespective of the type of exercise programme followed, there was a significant increase in peak power (z=-1.98; P=0.05) and normalised oxygen uptake during unloaded cycling (z =-2.00; P=0.05). At discharge from the exercise programmes, the cardiovascular response to sub-maximal exercise had significantly changed (t(360) =-4.62; p<0.01).                                                                                                                                                                                                                                           CONCLUSION: The response in people with MS at maximal and sub-maximal levels of physical exercise following a twelve week programme is analogous to non-diseased adults.                                                                                                                                                                                                                                                         CLINICAL REHABILITATION IMPACT: Cardiovascular adaptation in people with MS following a twelve week exercise programme suggests deconditioning rather than autonomic dysfunction caused by the disease.

KW - Multiple sclerosis

KW - Exercise

KW - Adaption, physiological

KW - Cardiovascular deconditioning

M3 - Article

VL - 49

SP - 765

EP - 774

JO - Annals of Physical and Rehabilitation Medicine

JF - Annals of Physical and Rehabilitation Medicine

SN - 1877-0657

IS - 6

ER -