Cardiac function is not associated with glucose control in older women

Charlotte Jones, Milos Markovic, Sarah Charman, Nduka Okwose, Srdjan Ivkovic, Robert Ropret, Branka Markovic, Sanja Mandaric, Miljan Grbovic, Guy A MacGowan, Djordje G Jakovljevic

Research output: Contribution to journalArticlepeer-review


The present study evaluated the effect of age on glucose tolerance and cardiac function and assessed the relationship between metabolic control and cardiac function and performance. Thirty-four healthy women aged 40 to 81 years were divided into two age groups: younger (≤50 years of age, N = 19) and older (≥60 years of age, N = 15). Participants performed an oral glucose tolerance test and a graded cardiopulmonary exercise test with non-invasive haemodynamic measurements. Compared to younger, older women demonstrated significantly higher 2-hour glucose (4.67 ± 1.01 vs 6.08 ± 1.54 mmol/l, P < 0.01), but lower peak exercise O2 consumption (1.96 ± 0.44 vs 1.38 ± 0.26 l/min, P < 0.01) and cardiac power output (4.06 ± 0.76 vs 3.35 ± 0.73 W, P = 0.01). When data from all study participants were combined, there was a significant negative relationship between 2-hour glucose and peak cardiac power (r = -0.39, P = 0.02), and peak O2 consumption (r = -0.40, P = 0.02). The strength of these relationships was affected by age, with moderate negative relationship identified between 2-hour glucose and peak cardiac power output in younger compared to older participants (r = -0.38, P = 0.11 vs. r = -0.09, P = 0.75). Metabolic control and cardiac function decline with age. The lack of relationship between glucose control and cardiac power may suggest that metabolic control does not influence cardiac function and performance in older women.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalExperimental Gerontology
Early online date20 Dec 2018
Publication statusPublished - Feb 2019
Externally publishedYes

Bibliographical note

Copyright © 2018 Elsevier Inc. All rights reserved.


  • Adipose Tissue/physiology
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging/physiology
  • Cross-Sectional Studies
  • Exercise/physiology
  • Female
  • Glucose Intolerance
  • Heart/physiology
  • Humans
  • Middle Aged
  • Prospective Studies


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