Carbon nanotubes assisted analytical detection – Sensing/delivery cues for environmental and biomedical monitoring

Tahir Rasheed, Adeel Ahmad Hassan, Fahmeeda Kausar, Farooq Sher, Muhammad Bilal, Hafiz M.N. Iqbal

Research output: Contribution to journalArticle

Abstract

The architecture of carbon nanotubes (CNTs) demonstrate phenomenal electronic, mechanical, biological and thermal attributes for highly requisite real-time applications. For instance, electronic and biological features of CNTs are surprisingly striking to engineer robust sensing and/or delivery cues for environmental, analytical diagnostics, and biomedical settings. With CNTs enforcement, several types of pristine and hybrid nanomaterials have been fabricated, though using different support carriers and synthetic or biological materials and used as sensory items or exploited as drug delivery systems (DDSs). Regardless of intensive research and applied potentialities of CNTs, several concerns, such as biodegradability, biotoxicity, and biosafety remains challenging and should be dealt with care prior to design and fabrication. This is mainly because of the lacking standardized protocols and ramification of pristine CNTs or CNTs-based hybrid nano-constructs on the ecosystem and human body are not well-established. For the futuristic use of these remarkable materials in the environmental, analytical diagnostics, and biomedical settings, their biological attributes and multifunctional characteristics must be elucidated with state-of-the-art. Herein, we reviewed CNTs-assisted analytical detection potentialities at large, and sensing/delivery potentialities of CNTs-based cues, in particular for environmental and biomedical monitoring. Several examples are given with particular emphasis to biosensors, DDSs, and implantations of CNTs-based cues to recognize viruses, cancerous cells, glucose, DNA, volatile organic compounds (VOCs) and various inorganic gases. The review is wrapped-up with concluding notes and brief outlook over the futuristic developments to further insight the CNTs-based robust cues and their perspectives for commercialization.
Original languageEnglish
Article number116066
JournalTrAC - Trends in Analytical Chemistry
Volume132
Early online date8 Oct 2020
DOIs
Publication statusPublished - Nov 2020

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in TrAC - Trends in Analytical Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in TrAC - Trends in Analytical Chemistry, 132 (2020) DOI: 10.1016/j.trac.2020.116066

© 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

  • Analytical detection
  • Biomolecules
  • Biosensors
  • Carbon nanotubes
  • Drug release carriers
  • Environmental and biomedical settings
  • Nano-cues

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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