Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019

Global Burden of Disease 2019 Cancer Collaboration

    Research output: Contribution to journalArticlepeer-review

    1352 Citations (Scopus)
    171 Downloads (Pure)

    Abstract

    Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden.

    Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019.

    Evidence Review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs).

    Findings: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles.

    Conclusions and Relevance: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

    Original languageEnglish
    Pages (from-to)420-444
    Number of pages25
    JournalJAMA Oncology
    Volume8
    Issue number3
    Early online date30 Dec 2021
    DOIs
    Publication statusPublished - 1 Mar 2022

    Bibliographical note

    This is an open access article distributed under the terms of the CC-BY License. © 2021 Global Burden of Disease 2019 Cancer Collaboration. JAMA Oncology.

    Funder

    Funding/Support: The Institute for Health Metrics and Evaluation received funding from the Bill & Melinda Gates Foundation and the American Lebanese Syrian Associated Charities. Dr Aljunid acknowledges the Department of Health Policy and Management of Kuwait University and the International Centre for Casemix and Clinical Coding, National University of Malaysia for the approval and support to participate in this research project. Dr Bhaskar acknowledges institutional support from the NSW Ministry of Health and NSW Health Pathology. Dr Bärnighausen was supported by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, which is funded by the German Federal Ministry of Education and Research. Dr Braithwaite acknowledges funding from the National Institutes of Health/ National Cancer Institute. Dr Conde acknowledges financial support from the European Research Council ERC Starting Grant agreement No 848325. Dr Costa acknowledges her grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundação para a Ciência e Tecnologia, IP under the Norma Transitória grant DL57/2016/CP1334/CT0006. Dr Ghith acknowledges support from a grant from Novo Nordisk Foundation (NNF16OC0021856). Dr Glasbey is supported by a National Institute of Health Research Doctoral Research Fellowship. Dr Vivek Kumar Gupta acknowledges funding support from National Health and Medical Research Council Australia. Dr Haque thanks Jazan University, Saudi Arabia for providing access to the Saudi Digital Library for this research study. Drs Herteliu, Pana, and Ausloos are partially supported by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. Dr Hugo received support from the Higher Education Improvement Coordination of the Brazilian Ministry of Education for a sabbatical period at the Institute for Health Metrics and Evaluation, between September 2019 and August 2020. Dr Sheikh Mohammed Shariful Islam acknowledges funding by a National Heart Foundation of Australia Fellowship and National Health and Medical Research Council Emerging Leadership Fellowship. Dr Jakovljevic acknowledges support through grant OI 175014 of the Ministry of Education Science and Technological Development of the Republic of Serbia. Dr Katikireddi acknowledges funding from a NHS Research Scotland Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_00022/2), and the Scottish Government Chief Scientist Office (SPHSU17). Dr Md Nuruzzaman Khan acknowledges the support of Jatiya Kabi Kazi Nazrul Islam University, Bangladesh. Dr Yun Jin Kim was supported by the Research Management Centre, Xiamen University Malaysia (XMUMRF/2020-C6/ITCM/0004). Dr Koulmane Laxminarayana acknowledges institutional support from Manipal Academy of Higher Education. Dr Landires is a member of the Sistema Nacional de Investigación, which is supported by Panama’s Secretaría Nacional de Ciencia, Tecnología e Innovación. Dr Loureiro was supported by national funds through Fundação para a Ciência e Tecnologia under the Scientific Employment Stimulus–Institutional Call (CEECINST/00049/2018). Dr Molokhia is supported by the National Institute for Health Research Biomedical Research Center at Guy’s and St Thomas’ National Health Service Foundation Trust and King’s College London. Dr Moosavi appreciates NIGEB's support. Dr Pati acknowledges support from the SIAN Institute, Association for Biodiversity Conservation & Research. Dr Rakovac acknowledges a grant from the government of the Russian Federation in the context of World Health Organization Noncommunicable Diseases Office. Dr Samy was supported by a fellowship from the Egyptian Fulbright Mission Program. Dr Sheikh acknowledges support from Health Data Research UK. Drs Adithi Shetty and Unnikrishnan acknowledge support given by Kasturba Medical College, Mangalore, Manipal Academy of Higher Education. Dr Pavanchand H. Shetty acknowledges Manipal Academy of Higher Education for their research support. Dr Diego Augusto Santos Silva was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil Finance Code 001 and is supported in part by CNPq (302028/2018-8). Dr Zhu acknowledges the Cancer Prevention and Research Institute of Texas grant RP210042.

    Funding

    Funding/Support: The Institute for Health Metrics and Evaluation received funding from the Bill & Melinda Gates Foundation and the American Lebanese Syrian Associated Charities. Dr Aljunid acknowledges the Department of Health Policy and Management of Kuwait University and the International Centre for Casemix and Clinical Coding, National University of Malaysia for the approval and support to participate in this research project. Dr Bhaskar acknowledges institutional support from the NSW Ministry of Health and NSW Health Pathology. Dr Bärnighausen was supported by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, which is funded by the German Federal Ministry of Education and Research. Dr Braithwaite acknowledges funding from the National Institutes of Health/ National Cancer Institute. Dr Conde acknowledges financial support from the European Research Council ERC Starting Grant agreement No 848325. Dr Costa acknowledges her grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundação para a Ciência e Tecnologia, IP under the Norma Transitória grant DL57/2016/CP1334/CT0006. Dr Ghith acknowledges support from a grant from Novo Nordisk Foundation (NNF16OC0021856). Dr Glasbey is supported by a National Institute of Health Research Doctoral Research Fellowship. Dr Vivek Kumar Gupta acknowledges funding support from National Health and Medical Research Council Australia. Dr Haque thanks Jazan University, Saudi Arabia for providing access to the Saudi Digital Library for this research study. Drs Herteliu, Pana, and Ausloos are partially supported by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. Dr Hugo received support from the Higher Education Improvement Coordination of the Brazilian Ministry of Education for a sabbatical period at the Institute for Health Metrics and Evaluation, between September 2019 and August 2020. Dr Sheikh Mohammed Shariful Islam acknowledges funding by a National Heart Foundation of Australia Fellowship and National Health and Medical Research Council Emerging Leadership Fellowship. Dr Jakovljevic acknowledges support through grant OI 175014 of the Ministry of Education Science and Technological Development of the Republic of Serbia. Dr Katikireddi acknowledges funding from a NHS Research Scotland Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_00022/2), and the Scottish Government Chief Scientist Office (SPHSU17). Dr Md Nuruzzaman Khan acknowledges the support of Jatiya Kabi Kazi Nazrul Islam University, Bangladesh. Dr Yun Jin Kim was supported by the Research Management Centre, Xiamen University Malaysia (XMUMRF/2020-C6/ITCM/0004). Dr Koulmane Laxminarayana acknowledges institutional support from Manipal Academy of Higher Education. Dr Landires is a member of the Sistema Nacional de Investigación, which is supported by Panama’s Secretaría Nacional de Ciencia, Tecnología e Innovación. Dr Loureiro was supported by national funds through Fundação para a Ciência e Tecnologia under the Scientific Employment Stimulus–Institutional Call (CEECINST/00049/2018). Dr Molokhia is supported by the National Institute for Health Research Biomedical Research Center at Guy’s and St Thomas’ National Health Service Foundation Trust and King’s College London. Dr Moosavi appreciates NIGEB's support. Dr Pati acknowledges support from the SIAN Institute, Association for Biodiversity Conservation & Research. Dr Rakovac acknowledges a grant from the government of the Russian Federation in the context of World Health Organization Noncommunicable Diseases Office. Dr Samy was supported by a fellowship from the Egyptian Fulbright Mission Program. Dr Sheikh acknowledges support from Health Data Research UK. Drs Adithi Shetty and Unnikrishnan acknowledge support given by Kasturba Medical College, Mangalore, Manipal Academy of Higher Education. Dr Pavanchand H. Shetty acknowledges Manipal Academy of Higher Education for their research support. Dr Diego Augusto Santos Silva was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil Finance Code 001 and is supported in part by CNPq (302028/2018-8). Dr Zhu acknowledges the Cancer Prevention and Research Institute of Texas grant RP210042.

    FundersFunder number
    Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
    Arthritis Research Canada
    Asbestos Diseases Research Institute
    Avicenna Medical
    Avicenna Medical and Clinical Research Institute
    Biomedical Research Networking Center for Mental Health Network (CiberSAM)
    Romanian National Authority for Scientific Research and InnovationPN-III-P4-ID-PCCF-2016-0084
    Institucio Catalana de Recerca i Estudis Avançats (ICREA)
    Fundação para a Ciência e a Tecnologia
    Baku State University
    University of Baghdad
    New Hospitals LTD
    University of Gondar
    Tulane University
    Jagiellonian University Medical College
    Kuwait University
    Kuwait University
    National Taiwan Normal University
    Sheri Kashmir Institute of Medical Sciences
    United Arab Emirates University
    Peking Union Medical College Hospital
    Hamadan University of Medical Sciences
    Oslo Metropolitan University
    M M Joshi Eye Institute
    Medanta Hospital
    Hacettepe University
    University of Dhaka
    Imperial College London
    Case Western Reserve University
    Fulbright Program
    Else-Kröner-Fresenius-Foundation
    Fundação para a Ciência e a Tecnologia
    Universitas Airlangga
    Universiti Brunei Darussalam
    United Arab Emirates University
    Finnish Cancer Foundation
    Imam Abdulrahman Bin Faisal university
    Fundação para a Ciência e a TecnologiaDL57/2016/CP1334/CT0006
    Guy’s and St Thomas’ NHS Foundation Trust
    HDRUK
    Hellenic Cardiology Society
    Indonesian Public Health Association
    National Research Council
    Seoul National University
    The Iranian Academy of Medical Sciences
    Jagiellonian University Medical College
    Jatiya Kabi Kazi Nazrul Islam University
    Kasturba Medical College
    Kasturba Medical College
    Kristiania University College
    University of Porto
    Lerner Research Institute
    Manipal Academy of Higher EducationCEECINST/ 00049/2018
    University of Sharjah
    Medanta Hospital
    Human Resources for Health in the Republic of Rwanda
    Eastern Virginia Medical School
    Ministry of Health
    Ministry of Labour and Social Justice
    NSW Ministry of Health
    National Centre for Disease Informatics and Research
    Guy’s and St Thomas’ NHS Foundation Trust
    National Hepatology and Tropical Medicine Research Institute
    NIHR Guy's and St Thomas' Biomedical Research Centre
    University of Texas System
    Ministry of Health and Population
    United Nations Population Fund Peru
    Xiamen University, Malaysia
    Russian Institute for Advanced Study
    SIAN Institute, Association for Biodiversity Conservation & Research
    Sant Boi de Llobregat, Spain
    A.T. Still University
    Instituto Politécnico do Porto
    Monash University
    University of British Columbia
    University of Georgia
    Xiamen University, Malaysia
    Fundação para a Ciência e a Tecnologia
    Scottish Government Chief Scientist OfficeSPHSU17
    University North
    UNIVERSITA DEGLI STUDI DI CATANIA
    University of Environment and Sustainable Development
    World Health Organization Noncommunicable Diseases Office
    Xiamen University, Malaysia XMUMRF/2020-C6/ITCM/0004
    National Institutes of Health
    National Cancer Institute
    Bill and Melinda Gates Foundation
    American Heart Association
    World Health Organization
    Illinois Department of Public Health
    Cancer Prevention and Research Institute of TexasRP210042
    Cancer Prevention and Research Institute of Texas
    Alexander von Humboldt-Stiftung
    St. Baldrick's Foundation
    American Society of Clinical Oncology
    United Nations Population Fund
    University of Pennsylvania
    Jackson State University
    Cleveland Clinic
    Tulane University
    Ohio University
    Case Western Reserve University
    McGill University
    King's College London
    Wellcome Trust
    American Lebanese Syrian Associated Charities
    The University of Texas Health Science Center at Houston
    Eastern Virginia Medical School
    University of Washington
    University of Washington
    Ministry of Health and Population
    Medical Research CouncilMC_UU_00022/2
    Medical Research Council
    National Institute for Health and Care Research
    Imperial College London
    European Commission
    European Research CouncilSFRH/ BHD/110001/2015, 848325
    European Research Council
    National Health and Medical Research Council
    National Heart Foundation of AustraliaOI 175014
    National Heart Foundation of Australia
    Coventry University
    Indian Council of Medical Research
    Deutsche Forschungsgemeinschaft
    University of Sydney
    Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
    Austrian National Foundation for Research, Technology and Development
    Cairo University
    Seoul National University
    Gachon University
    Ministero della Salute
    Conselho Nacional de Desenvolvimento Científico e Tecnológico302028/2018-8
    Conselho Nacional de Desenvolvimento Científico e Tecnológico
    Jordan University of Science and Technology
    King Abdulaziz University
    Päivikki ja Sakari Sohlbergin Säätiö
    National Research Council
    UNIVERSITA DEGLI STUDI DI CATANIA
    Universiti Kebangsaan Malaysia
    Ministarstvo Prosvete, Nauke i Tehnološkog RazvojaSCAF/15/02
    Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
    Université catholique de Louvain
    University of British Columbia
    Hacettepe University
    Romanian National Authority for Scientific Research and Innovation
    Shahid Beheshti University of Medical Sciences
    United Arab Emirates University
    Sigrid Juséliuksen Säätiö
    Baku State University
    National Taiwan Normal University
    National Institute for Genetic Engineering and Biotechnology
    Secretaría Nacional de Ciencia, Tecnología e Innovación
    Imam Abdulrahman Bin Faisal university
    Universitas Airlangga
    European Regional Development Fund
    NSW Ministry of Health
    Russian Government
    Novo Nordisk FondenNNF16OC0021856
    Novo Nordisk Fonden
    Tokyo Metropolitan University
    Pontifical Catholic University of Chile
    Kementerian Pendidikan Malaysia
    Coventry University
    Hellenic Atherosclerosis Society

    Fingerprint

    Dive into the research topics of 'Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019'. Together they form a unique fingerprint.

    Cite this