Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response?

Pierre Olivier Lang; Richard Aspinall

doi:10.3390/nu7032044

Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response?

Pierre Olivier Lang
, Richard Aspinall

Anglia Ruskin University

Research output: Contribution to journal › Review article › peer-review

46 Citations (Scopus)

59 Downloads (Pure)

Abstract

Vitamin D (VitD), which is well known for its classic role in the maintenance of bone mineral density, has now become increasingly studied for its extra-skeletal roles. It has an important influence on the body’s immune system and modulates both innate and adaptive immunity and regulates the inflammatory cascade. In this review our aim was to describe how VitD might influence immune responsiveness and its potential modulating role in vaccine immunogenicity. In the first instance, we consider the literature that may provide molecular and genetic support to the idea that VitD status may be related to innate and/or adaptive immune response with a particular focus on vaccine immunogenicity and then discuss observational studies and controlled trials of VitD supplementation conducted in humans. Finally, we conclude with some knowledge gaps surrounding VitD and vaccine response, and that it is still premature to recommend “booster” of VitD at vaccination time to enhance vaccine response.

Original language	English
Pages (from-to)	2044-2060
Number of pages	17
Journal	Nutrients
Volume	7
Issue number	3
DOIs	https://doi.org/10.3390/nu7032044
Publication status	Published - 20 Mar 2015
Externally published	Yes

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

25(OH)VitD
Adaptive immunity
Calcitriol
Cholecalciferol
Immune cells
Immunogenicity
Innate immunity
Vaccine
Vitamin D

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

Access to Document

10.3390/nu7032044Licence: CC BY

PublishedFinal published version, 732 KBLicence: CC BY

Cite this

@article{e338fccc5bd94f0b93cb1572c0d9f008,

title = "Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response?",

abstract = "Vitamin D (VitD), which is well known for its classic role in the maintenance of bone mineral density, has now become increasingly studied for its extra-skeletal roles. It has an important influence on the body{\textquoteright}s immune system and modulates both innate and adaptive immunity and regulates the inflammatory cascade. In this review our aim was to describe how VitD might influence immune responsiveness and its potential modulating role in vaccine immunogenicity. In the first instance, we consider the literature that may provide molecular and genetic support to the idea that VitD status may be related to innate and/or adaptive immune response with a particular focus on vaccine immunogenicity and then discuss observational studies and controlled trials of VitD supplementation conducted in humans. Finally, we conclude with some knowledge gaps surrounding VitD and vaccine response, and that it is still premature to recommend “booster” of VitD at vaccination time to enhance vaccine response.",

keywords = "25(OH)VitD, Adaptive immunity, Calcitriol, Cholecalciferol, Immune cells, Immunogenicity, Innate immunity, Vaccine, Vitamin D",

author = "Lang, \{Pierre Olivier\} and Richard Aspinall",

note = "This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).",

year = "2015",

month = mar,

day = "20",

doi = "10.3390/nu7032044",

language = "English",

volume = "7",

pages = "2044--2060",

journal = "Nutrients",

issn = "2072-6643",