Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response?

Pierre Olivier Lang, Richard Aspinall

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)
29 Downloads (Pure)


Vitamin D (VitD), which is well known for its classic role in the maintenance of bone mineral density, has now become increasingly studied for its extra-skeletal roles. It has an important influence on the body’s immune system and modulates both innate and adaptive immunity and regulates the inflammatory cascade. In this review our aim was to describe how VitD might influence immune responsiveness and its potential modulating role in vaccine immunogenicity. In the first instance, we consider the literature that may provide molecular and genetic support to the idea that VitD status may be related to innate and/or adaptive immune response with a particular focus on vaccine immunogenicity and then discuss observational studies and controlled trials of VitD supplementation conducted in humans. Finally, we conclude with some knowledge gaps surrounding VitD and vaccine response, and that it is still premature to recommend “booster” of VitD at vaccination time to enhance vaccine response.

Original languageEnglish
Pages (from-to)2044-2060
Number of pages17
Issue number3
Publication statusPublished - 20 Mar 2015
Externally publishedYes

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).


  • 25(OH)VitD
  • Adaptive immunity
  • Calcitriol
  • Cholecalciferol
  • Immune cells
  • Immunogenicity
  • Innate immunity
  • Vaccine
  • Vitamin D

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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