Calcium Activation of Parvalbumin Neurons Induced by Electrical Motor Cortex Stimulation

Ruixue Wang, Jiawei Han, Wang Xi, Yuhang Xu, Dingchang Zheng, Heecheon You, Shaomin Zhang

    Research output: Chapter in Book/Report/Conference proceedingConference proceedingpeer-review

    Abstract

    Electrical motor cortex stimulation (EMCS) has been used for Parkinson's Disease (PD) treatment. Some studies found that distinct cell types might lead to selective effects. As the largest subgroup of interneurons, Parvalbumin (PV) neurons have been reported to be involved in the mechanisms of therapeutic efficacy for PD treatment. However, little is known about their responses to the EMCS. In this study, we used in-vivo two-photon imaging to record calcium activities of PV neurons (specific type) and all neurons (non-specific type) in layer 2/3 primary motor cortex (MI) during EMCS with various stimulus parameters. We found PV neurons displayed different profiles of activation property compared to all neurons. The cathodal polarity preference of PV neurons decreased at a high-frequency stimulus. The calcium transients of PV neurons generated by EMCS trended to be with large amplitude and short active duration. The optimal activation frequency of PV neurons is higher than that of all neurons. These results improved our understanding of the selective effects of EMCS on specific cell types, which could bring more effective stimulation protocols for PD treatment.

    Original languageEnglish
    Title of host publication2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
    PublisherIEEE
    Pages2353-2356
    Number of pages4
    Volume2022
    ISBN (Electronic)978-1-7281-2782-8
    ISBN (Print)978-1-7281-2783-5
    DOIs
    Publication statusPublished - 8 Sept 2022
    Event44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. - Glasgow, United Kingdom
    Duration: 11 Jul 202215 Jul 2022

    Publication series

    NameAnnual International Conference of the IEEE Engineering in Medicine and Biology Society.
    PublisherIEEE
    ISSN (Print)2375-7477
    ISSN (Electronic)2694-0604

    Conference

    Conference44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
    Country/TerritoryUnited Kingdom
    CityGlasgow
    Period11/07/2215/07/22

    Keywords

    • Calcium/metabolism
    • Interneurons/metabolism
    • Motor Cortex
    • Neurons/physiology
    • Parvalbumins/metabolism

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