Calcitonin Gene-Related Peptide and Adrenomedullin Receptors

Hoor Ayub, Rachael Grime, David Poyner, Mark Wheatley

    Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionarypeer-review

    Abstract

    Calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and adrenomedullin 2 (AM2) are related peptides, which are potent vasodilators. The receptors for these peptides are unusual, comprising a G-protein-coupled receptor (GPCR) with receptor activity-modifying proteins (RAMPs). The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, (the CGRPR), whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor (AM1 and AM2 receptors). CGRP is also a potent agonist at the AMY1(a) receptor, a heterodimer between the calcitonin receptor (CTR) and RAMP1. This article covers the pharmacology of these receptors, their structure, distribution, and potential involvement in disease.
    Original languageEnglish
    Title of host publicationReference Module in Life Sciences 2020
    PublisherElsevier
    DOIs
    Publication statusPublished - 18 Nov 2020

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