C-type lectin receptors and cytokines in fungal immunity

Simon Vautier, Donna M. MacCallum, Gordon D. Brown

Research output: Contribution to journalReview article

70 Citations (Scopus)

Abstract

Fungi are the cause of opportunistic infections, predominantly in immunocompromised individuals although, primary fungal infections can occur in apparently healthy individuals. Successful host defence requires an effective innate and adaptive immune response. Central to host immune responses are the induction of cytokines; the signals which help to activate the innate immune system and which play a central role in directing the development of pathogen-specific immunity. C-type lectins play a central role in the recognition and shaping of immune responses to fungal pathogens, in part, through the induction and modulation of cytokine responses. Understanding which cytokines induce protective responses to these pathogens and how C-type lectins and other receptors direct cytokine production may allow development of novel antifungal therapies. Here we review the C-type lectins, their influence on cytokine production and subsequent immune responses in antifungal immunity.

Original languageEnglish
Pages (from-to)89-99
Number of pages11
JournalCytokine
Volume58
Issue number1
Early online date15 Sep 2011
DOIs
Publication statusPublished - 1 Apr 2012
Externally publishedYes

Keywords

  • C-type lectin
  • Cytokine
  • Fungi
  • Innate immunity
  • Signalling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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