Burden of chronic cough on social participation, healthcare resource utilisation and activities of daily living in the Canadian Longitudinal Study on Aging (CLSA)

Imran Satia; Alexandra J. Mayhew; Nazmul Sohel; Om Kurmi; Kieran J Killian; Paul M O'Byrne; Parminder Raina

doi:10.1016/j.rmed.2023.107431

Burden of chronic cough on social participation, healthcare resource utilisation and activities of daily living in the Canadian Longitudinal Study on Aging (CLSA)

Imran Satia, Alexandra J. Mayhew, Nazmul Sohel, Om Kurmi, Kieran J Killian, Paul M O'Byrne, Parminder Raina

Centre for Healthcare and Communities

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Abstract

Background: Chronic cough is a common troublesome condition, but it is unclear whether dry or productive chronic cough and sex, impacts the burden of cough differently.

Methods: The Canadian Longitudinal Study on Aging is a nationally generalizable, stratified random sample of adults aged 45–85 years. Chronic cough was identified based on a self-reported daily cough in the last 12 months assessed at baseline (2011–2015) and follow-up (2015–2018). Odds ratios (95 % CI) for cough status and change in social participation activities (SPA), healthcare resource utilisation (HCRU), basic activities of daily living (ADLs) and instrumental activities of daily living (IADLs) were estimated using a weighted generalised estimating equation (WGEE). Results were stratified by sex, and adjusted for age, sex, smoking, body mass index, education, respiratory diseases and retirement status.

Results: Overall, chronic cough was associated with less SPA, greater HCRU and impaired ADL/IADLs. Productive chronic cough in males was associated with SPA limited by health, ED visits and hospitalisation. Females with productive chronic cough was associated with reduced frequency of SPA and ED visit. Dry chronic cough in females was associated with SPA limited by health and ED visits. Both types of cough was associated with at least 1 impaired basic ADL, but only in females with productive chronic cough was there an association with any impairment in IADLs.

Conclusion: Chronic cough is associated with a greater burden on social participation, healthcare use and personal care.

Original language	English
Article number	107431
Number of pages	9
Journal	Respiratory Medicine
Volume	219
Early online date	24 Oct 2023
DOIs	https://doi.org/10.1016/j.rmed.2023.107431
Publication status	Published - 1 Nov 2023

Bibliographical note

© 2023, Elsevier. Licensed under the Creative Commons Attribution NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

Funder

Supported in part by a research grant from Investigator-Initiated Studies Program of Merck Canada Inc. The opinions expressed in this paper are those of the authors and do not necessarily represent those of Merck Canada Inc. I.S. is currently supported by the E.J. Moran Campbell Early Career Award, Department of Medicine, McMaster University.

Funding

Supported in part by a research grant from Investigator-Initiated Studies Program of Merck Canada Inc. The opinions expressed in this paper are those of the authors and do not necessarily represent those of Merck Canada Inc. I.S. is currently supported by the E.J. Moran Campbell Early Career Award, Department of Medicine, McMaster University.

Funders	Funder number
Merck Canada
McMaster University

Keywords

Chronic cough
Quality of life
Epidemiology
CLSA

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10.1016/j.rmed.2023.107431

Kurmi2023AAMAccepted author manuscript, 862 KBLicence: CC BY-NC-ND

Cite this

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title = "Burden of chronic cough on social participation, healthcare resource utilisation and activities of daily living in the Canadian Longitudinal Study on Aging (CLSA)",

abstract = "Background: Chronic cough is a common troublesome condition, but it is unclear whether dry or productive chronic cough and sex, impacts the burden of cough differently.Methods: The Canadian Longitudinal Study on Aging is a nationally generalizable, stratified random sample of adults aged 45–85 years. Chronic cough was identified based on a self-reported daily cough in the last 12 months assessed at baseline (2011–2015) and follow-up (2015–2018). Odds ratios (95 % CI) for cough status and change in social participation activities (SPA), healthcare resource utilisation (HCRU), basic activities of daily living (ADLs) and instrumental activities of daily living (IADLs) were estimated using a weighted generalised estimating equation (WGEE). Results were stratified by sex, and adjusted for age, sex, smoking, body mass index, education, respiratory diseases and retirement status.Results: Overall, chronic cough was associated with less SPA, greater HCRU and impaired ADL/IADLs. Productive chronic cough in males was associated with SPA limited by health, ED visits and hospitalisation. Females with productive chronic cough was associated with reduced frequency of SPA and ED visit. Dry chronic cough in females was associated with SPA limited by health and ED visits. Both types of cough was associated with at least 1 impaired basic ADL, but only in females with productive chronic cough was there an association with any impairment in IADLs.Conclusion: Chronic cough is associated with a greater burden on social participation, healthcare use and personal care. ",

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AU - Killian, Kieran J

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AU - Raina, Parminder

N1 - © 2023, Elsevier. Licensed under the Creative Commons Attribution NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

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N2 - Background: Chronic cough is a common troublesome condition, but it is unclear whether dry or productive chronic cough and sex, impacts the burden of cough differently.Methods: The Canadian Longitudinal Study on Aging is a nationally generalizable, stratified random sample of adults aged 45–85 years. Chronic cough was identified based on a self-reported daily cough in the last 12 months assessed at baseline (2011–2015) and follow-up (2015–2018). Odds ratios (95 % CI) for cough status and change in social participation activities (SPA), healthcare resource utilisation (HCRU), basic activities of daily living (ADLs) and instrumental activities of daily living (IADLs) were estimated using a weighted generalised estimating equation (WGEE). Results were stratified by sex, and adjusted for age, sex, smoking, body mass index, education, respiratory diseases and retirement status.Results: Overall, chronic cough was associated with less SPA, greater HCRU and impaired ADL/IADLs. Productive chronic cough in males was associated with SPA limited by health, ED visits and hospitalisation. Females with productive chronic cough was associated with reduced frequency of SPA and ED visit. Dry chronic cough in females was associated with SPA limited by health and ED visits. Both types of cough was associated with at least 1 impaired basic ADL, but only in females with productive chronic cough was there an association with any impairment in IADLs.Conclusion: Chronic cough is associated with a greater burden on social participation, healthcare use and personal care.

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Burden of chronic cough on social participation, healthcare resource utilisation and activities of daily living in the Canadian Longitudinal Study on Aging (CLSA)

Abstract

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Keywords

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