Brownian dynamics simulations of the β2-adrenergic receptor extracellular loops: Evidence for helix movement in ligand binding?

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Brownian dynamics simulations of the gating mechanism of the extracellular loops of the β2-adrenergic receptor suggest that loop gating alone will not permit the larger ligands to bind and hence suggests that lateral helix movement is also required in the binding process.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalJournal of Molecular Structure: THEOCHEM
Volume469
Issue number1-3
Early online date17 Aug 1999
DOIs
Publication statusPublished - 1 Sep 1999
Externally publishedYes

Keywords

  • Brownian dynamics
  • Domain swapping
  • G-protein coupled receptors
  • Ligand binding
  • β-adrenergic receptor

ASJC Scopus subject areas

  • Biochemistry
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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