Body Mass Index and Risk of Parkinson, Alzheimer, Dementia, and Dementia mortality: A Systematic Review and Dose-response Meta-analysis of Cohort Studies Among 5 Million Participants

Jamal Rahmani, Arezoo Haghighian Roudsari, Hiba Bawadi, Cain Clark, Paul Ryan, Ammar Salehisahlabadi, Fatemeh Rahimi sakak, Jalaledin Mirzay Razaz

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)
    6 Downloads (Pure)

    Abstract

    Objective: Inconsistent results regarding the association between the Body Mass Index (BMI) and brain disorders have been reported. We performed this study to investigate the association between BMI and risk of Parkinson, Alzheimer, Dementia and Dementia-mortality. Methods: A systematic search was conducted up to April 2019 in MEDLINE/PubMed, SCOPUS, and Cochrane Library. Results pooled with random-effects model. Results: Totally, 29 articles which were included in this study with4,978,621 participants. The pooled HR for Parkinson’s in the underweight person was 1.20 (95%CI1.10–1.30). The pooled HR for dementia in underweight and overweight category was 1.23 (95%CI = 1.05–1.45) and 0.88 (95%CI = 0.83–0.94), respectively. There is not any significant relation between each categories of BMI and Alzheimer disease. The pooled HR for dementia in underweight and overweight category was 1.36 (95%CI = 1.14–1.63) and 0.81 (95%CI = 0.49–1.33), respectively. The non-linear association between BMI and risk of Dementia-mortality was significant (p = 0.001,Coeff = 0.003). Conclusion: This study highlights underweight related to increase incidence of Parkinson, Dementia, and Dementia mortality but no on Alzheimer disease.

    Original languageEnglish
    Pages (from-to)423-431
    Number of pages9
    JournalNutritional Neuroscience
    Volume25
    Issue number3
    Early online date27 Oct 2020
    DOIs
    Publication statusPublished - 4 Mar 2022

    Keywords

    • Alzheimer's disease
    • Body mass index
    • Dementia
    • Parkinson's disease
    • body fat
    • meta-analysis
    • mortality‌
    • obesity

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Neuroscience(all)
    • Nutrition and Dietetics

    Fingerprint

    Dive into the research topics of 'Body Mass Index and Risk of Parkinson, Alzheimer, Dementia, and Dementia mortality: A Systematic Review and Dose-response Meta-analysis of Cohort Studies Among 5 Million Participants'. Together they form a unique fingerprint.

    Cite this