Body Mass Index and Risk of Inflammatory Bowel Disease: a systematic review and dose-response meta-analysis of cohort studies of over a million participants

Jamal Rahmani, Hamed Kord Varkaneh, Azita Hekmatdoost, Jacqueline Thomps, Cain Clark, Ammar Salehisahlabadi, Andrew S Day, Kevan Jacobson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The relationship between body mass index (BMI) and risk of inflammatory bowel disease (IBD) is controversial. We performed a dose-response meta-analysis to investigate the association between BMI and risk of incident ulcerative colitis (UC) and Crohn's disease (CD) using prospective cohort studies. A systematic search was conducted in MEDLINE/PubMed, SCOPUS, Cochrane, and Web of Science databases from inception to January 2019. DerSimonian and Laird random-effects model was used to estimate combined hazard ratios (HRs). Overall, 882 articles were screened, and 42 full-text articles were reviewed for inclusion using the study eligibility criteria. Five studies evaluated the association between BMI and IBD with 1 044 517 participants. Pooled results showed a significant association between participants affected by obesity and risk of CD (HR: 1.42, 95% CI: 1.18-1.71, I 2: 0.00). There was a significant nonlinear association between BMI and risk of CD (P =.01, coeff = 0.5024). Pooled results did not show any significant association between being underweight and risk of UC (HR: 1.07, 95% CI: 0.96-1.19, I 2: 0.00) or CD (HR: 1.11, 95% CI: 0.93-1.31, I 2: 12.8). There was no difference in the risk for UC among participants affected by obesity compared with participants categorized as having normal BMI (HR: 0.96, 95% CI: 0.80-1.14, I 2: 8.0). This systematic review and meta-analysis identified significant dose-response relationship between being affected by obesity, as a risk factor, and incidence of CD.

Original languageEnglish
Pages (from-to)1312-1320
Number of pages9
JournalObesity Reviews
Volume20
Issue number9
Early online date12 Jun 2019
DOIs
Publication statusPublished - Sep 2019

Fingerprint

Inflammatory Bowel Diseases
Meta-Analysis
Body Mass Index
Cohort Studies
Crohn Disease
Ulcerative Colitis
Obesity
Thinness
PubMed
MEDLINE
Databases
Prospective Studies
Incidence

Keywords

  • Inflammatory Bowel Disease
  • Body Mass Index
  • Crohn’s Disease
  • Ulcerative Colitis
  • Obesity
  • body mass index
  • Crohn's disease
  • ulcerative colitis
  • inflammatory bowel disease

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Body Mass Index and Risk of Inflammatory Bowel Disease: a systematic review and dose-response meta-analysis of cohort studies of over a million participants. / Rahmani, Jamal; Varkaneh, Hamed Kord ; Hekmatdoost, Azita ; Thomps, Jacqueline ; Clark, Cain; Salehisahlabadi, Ammar ; Day, Andrew S; Jacobson, Kevan .

In: Obesity Reviews, Vol. 20, No. 9, 09.2019, p. 1312-1320.

Research output: Contribution to journalArticle

Rahmani, Jamal ; Varkaneh, Hamed Kord ; Hekmatdoost, Azita ; Thomps, Jacqueline ; Clark, Cain ; Salehisahlabadi, Ammar ; Day, Andrew S ; Jacobson, Kevan . / Body Mass Index and Risk of Inflammatory Bowel Disease: a systematic review and dose-response meta-analysis of cohort studies of over a million participants. In: Obesity Reviews. 2019 ; Vol. 20, No. 9. pp. 1312-1320.
@article{16b1c0e0aeef46b086e4759c886a0ba1,
title = "Body Mass Index and Risk of Inflammatory Bowel Disease: a systematic review and dose-response meta-analysis of cohort studies of over a million participants",
abstract = "The relationship between body mass index (BMI) and risk of inflammatory bowel disease (IBD) is controversial. We performed a dose-response meta-analysis to investigate the association between BMI and risk of incident ulcerative colitis (UC) and Crohn's disease (CD) using prospective cohort studies. A systematic search was conducted in MEDLINE/PubMed, SCOPUS, Cochrane, and Web of Science databases from inception to January 2019. DerSimonian and Laird random-effects model was used to estimate combined hazard ratios (HRs). Overall, 882 articles were screened, and 42 full-text articles were reviewed for inclusion using the study eligibility criteria. Five studies evaluated the association between BMI and IBD with 1 044 517 participants. Pooled results showed a significant association between participants affected by obesity and risk of CD (HR: 1.42, 95{\%} CI: 1.18-1.71, I 2: 0.00). There was a significant nonlinear association between BMI and risk of CD (P =.01, coeff = 0.5024). Pooled results did not show any significant association between being underweight and risk of UC (HR: 1.07, 95{\%} CI: 0.96-1.19, I 2: 0.00) or CD (HR: 1.11, 95{\%} CI: 0.93-1.31, I 2: 12.8). There was no difference in the risk for UC among participants affected by obesity compared with participants categorized as having normal BMI (HR: 0.96, 95{\%} CI: 0.80-1.14, I 2: 8.0). This systematic review and meta-analysis identified significant dose-response relationship between being affected by obesity, as a risk factor, and incidence of CD.",
keywords = "Inflammatory Bowel Disease, Body Mass Index, Crohn’s Disease, Ulcerative Colitis, Obesity, body mass index, Crohn's disease, ulcerative colitis, inflammatory bowel disease",
author = "Jamal Rahmani and Varkaneh, {Hamed Kord} and Azita Hekmatdoost and Jacqueline Thomps and Cain Clark and Ammar Salehisahlabadi and Day, {Andrew S} and Kevan Jacobson",
year = "2019",
month = "9",
doi = "10.1111/obr.12875",
language = "English",
volume = "20",
pages = "1312--1320",
journal = "Obesity Reviews",
issn = "1467-7881",
publisher = "Wiley",
number = "9",

}

TY - JOUR

T1 - Body Mass Index and Risk of Inflammatory Bowel Disease: a systematic review and dose-response meta-analysis of cohort studies of over a million participants

AU - Rahmani, Jamal

AU - Varkaneh, Hamed Kord

AU - Hekmatdoost, Azita

AU - Thomps, Jacqueline

AU - Clark, Cain

AU - Salehisahlabadi, Ammar

AU - Day, Andrew S

AU - Jacobson, Kevan

PY - 2019/9

Y1 - 2019/9

N2 - The relationship between body mass index (BMI) and risk of inflammatory bowel disease (IBD) is controversial. We performed a dose-response meta-analysis to investigate the association between BMI and risk of incident ulcerative colitis (UC) and Crohn's disease (CD) using prospective cohort studies. A systematic search was conducted in MEDLINE/PubMed, SCOPUS, Cochrane, and Web of Science databases from inception to January 2019. DerSimonian and Laird random-effects model was used to estimate combined hazard ratios (HRs). Overall, 882 articles were screened, and 42 full-text articles were reviewed for inclusion using the study eligibility criteria. Five studies evaluated the association between BMI and IBD with 1 044 517 participants. Pooled results showed a significant association between participants affected by obesity and risk of CD (HR: 1.42, 95% CI: 1.18-1.71, I 2: 0.00). There was a significant nonlinear association between BMI and risk of CD (P =.01, coeff = 0.5024). Pooled results did not show any significant association between being underweight and risk of UC (HR: 1.07, 95% CI: 0.96-1.19, I 2: 0.00) or CD (HR: 1.11, 95% CI: 0.93-1.31, I 2: 12.8). There was no difference in the risk for UC among participants affected by obesity compared with participants categorized as having normal BMI (HR: 0.96, 95% CI: 0.80-1.14, I 2: 8.0). This systematic review and meta-analysis identified significant dose-response relationship between being affected by obesity, as a risk factor, and incidence of CD.

AB - The relationship between body mass index (BMI) and risk of inflammatory bowel disease (IBD) is controversial. We performed a dose-response meta-analysis to investigate the association between BMI and risk of incident ulcerative colitis (UC) and Crohn's disease (CD) using prospective cohort studies. A systematic search was conducted in MEDLINE/PubMed, SCOPUS, Cochrane, and Web of Science databases from inception to January 2019. DerSimonian and Laird random-effects model was used to estimate combined hazard ratios (HRs). Overall, 882 articles were screened, and 42 full-text articles were reviewed for inclusion using the study eligibility criteria. Five studies evaluated the association between BMI and IBD with 1 044 517 participants. Pooled results showed a significant association between participants affected by obesity and risk of CD (HR: 1.42, 95% CI: 1.18-1.71, I 2: 0.00). There was a significant nonlinear association between BMI and risk of CD (P =.01, coeff = 0.5024). Pooled results did not show any significant association between being underweight and risk of UC (HR: 1.07, 95% CI: 0.96-1.19, I 2: 0.00) or CD (HR: 1.11, 95% CI: 0.93-1.31, I 2: 12.8). There was no difference in the risk for UC among participants affected by obesity compared with participants categorized as having normal BMI (HR: 0.96, 95% CI: 0.80-1.14, I 2: 8.0). This systematic review and meta-analysis identified significant dose-response relationship between being affected by obesity, as a risk factor, and incidence of CD.

KW - Inflammatory Bowel Disease

KW - Body Mass Index

KW - Crohn’s Disease

KW - Ulcerative Colitis

KW - Obesity

KW - body mass index

KW - Crohn's disease

KW - ulcerative colitis

KW - inflammatory bowel disease

UR - http://www.scopus.com/inward/record.url?scp=85067639076&partnerID=8YFLogxK

U2 - 10.1111/obr.12875

DO - 10.1111/obr.12875

M3 - Article

VL - 20

SP - 1312

EP - 1320

JO - Obesity Reviews

JF - Obesity Reviews

SN - 1467-7881

IS - 9

ER -