Blood flow restriction attenuates eccentric exercise-induced muscle damage without perceptual and cardiovascular overload

Victor M Curty, Alexandre B Melo, Leonardo C Caldas, Lucas Guimarães-Ferreira, Nuno F de Sousa, Paula F Vassallo, Elisardo C Vasquez, Valério G Barauna

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17 Citations (Scopus)


The aim of this study was to evaluate the acute effects of high-intensity eccentric exercise (HI-ECC) combined with blood flow restriction (BFR) on muscle damage markers, and perceptual and cardiovascular responses. Nine healthy men (26 ± 1 years, BMI 24 ± 1 kg m- ²) underwent unilateral elbow extension in two conditions: without (HI-ECC) and with BFR (HI-ECC+BFR). The HI-ECC protocol corresponded to three sets of 10 repetitions with 130% of maximal strength (1RM). The ratings of perceived exertion (RPE) and pain (RPP) were measured after each set. Muscle damage was evaluated by range of motion (ROM), upper arm circumference (CIR) and muscle soreness using a visual analogue scale at different moments (pre-exercise, immediately after, 24 and 48 h postexercise). Systolic (SBP), diastolic (DBP), mean blood pressure (MBP) and heart rate (HR) were measured before exercise and after each set. RPP was higher in HI-ECC+BFR than in HI-ECC after each set. Range of motion decreased postexercise in both conditions; however, in HI-ECC+BFR group, it returned to pre-exercise condition earlier (post-24 h) than HI-ECC (post-48 h). CIR increased only in HI-ECC, while no difference was observed in HI-ECC+BFR condition. Regarding cardiovascular responses, MBP and SBP did not change at any moment. HR showed similar increases in both conditions during exercise while DBP decreased only in HI-ECC condition. Thus, BFR attenuated HI-ECC-induced muscle damage and there was no increase in cardiovascular responses.

Original languageEnglish
Pages (from-to)468-476
Number of pages9
JournalClinical Physiology and Functional Imaging
Issue number3
Early online date26 Apr 2017
Publication statusPublished - May 2018
Externally publishedYes

Bibliographical note

© 2017 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.


  • Adult
  • Blood Pressure
  • Cross-Over Studies
  • Elbow
  • Heart Rate
  • Hemodynamics
  • Humans
  • Male
  • Muscle Contraction
  • Muscle, Skeletal/blood supply
  • Myalgia/etiology
  • Pain Perception
  • Physical Endurance
  • Range of Motion, Articular
  • Regional Blood Flow
  • Resistance Training/adverse effects
  • Time Factors
  • Tourniquets


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