Biomimetics for the induction of bone formation

U Ripamonti; L Roden

doi:10.1586/ERD.10.17

Biomimetics for the induction of bone formation

U Ripamonti, L Roden

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The new strategy to initiate the induction of bone formation is to carve smart, self-inducing geometric cues assembled within biomimetic medical devices. These are endowed with the striking prerogative of differentiating myoblastic and/or pericytic stem cells into osteoblastic-like cells attached to the morphogenetic concavities; osteoblastic-like cells secrete osteogenic gene products of the TGF-β supergene family, further differentiating invading stem cells into osteoblastic-like cells, and initiating bone formation by induction as a secondary response.

Original language	English
Pages (from-to)	469-479
Number of pages	11
Journal	Expert Review of Medical Devices
Volume	7
Issue number	4
DOIs	https://doi.org/10.1586/ERD.10.17
Publication status	Published - 2010
Externally published	Yes

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10.1586/ERD.10.17

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abstract = "The new strategy to initiate the induction of bone formation is to carve smart, self-inducing geometric cues assembled within biomimetic medical devices. These are endowed with the striking prerogative of differentiating myoblastic and/or pericytic stem cells into osteoblastic-like cells attached to the morphogenetic concavities; osteoblastic-like cells secrete osteogenic gene products of the TGF-β supergene family, further differentiating invading stem cells into osteoblastic-like cells, and initiating bone formation by induction as a secondary response.",

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AB - The new strategy to initiate the induction of bone formation is to carve smart, self-inducing geometric cues assembled within biomimetic medical devices. These are endowed with the striking prerogative of differentiating myoblastic and/or pericytic stem cells into osteoblastic-like cells attached to the morphogenetic concavities; osteoblastic-like cells secrete osteogenic gene products of the TGF-β supergene family, further differentiating invading stem cells into osteoblastic-like cells, and initiating bone formation by induction as a secondary response.

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DO - 10.1586/ERD.10.17

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Biomimetics for the induction of bone formation

Abstract

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