Biomimetics for the induction of bone formation

U Ripamonti, L Roden

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The new strategy to initiate the induction of bone formation is to carve smart, self-inducing geometric cues assembled within biomimetic medical devices. These are endowed with the striking prerogative of differentiating myoblastic and/or pericytic stem cells into osteoblastic-like cells attached to the morphogenetic concavities; osteoblastic-like cells secrete osteogenic gene products of the TGF-β supergene family, further differentiating invading stem cells into osteoblastic-like cells, and initiating bone formation by induction as a secondary response.
Original languageEnglish
Pages (from-to)469-479
Number of pages11
JournalExpert Review of Medical Devices
Issue number4
Publication statusPublished - 2010
Externally publishedYes


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