Abstract
The new strategy to initiate the induction of bone formation is to carve smart, self-inducing geometric cues assembled within biomimetic medical devices. These are endowed with the striking prerogative of differentiating myoblastic and/or pericytic stem cells into osteoblastic-like cells attached to the morphogenetic concavities; osteoblastic-like cells secrete osteogenic gene products of the TGF-β supergene family, further differentiating invading stem cells into osteoblastic-like cells, and initiating bone formation by induction as a secondary response.
Original language | English |
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Pages (from-to) | 469-479 |
Number of pages | 11 |
Journal | Expert Review of Medical Devices |
Volume | 7 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |