Benefit of lifestyle-based T2DM prevention is influenced by prediabetes phenotype

Matthew D. Campbell, Thirunavukkarasu Sathish, Paul Z. Zimmet, Kavumpurathu R. Thankappan, Brian Oldenburg, David R. Owens, Jonathan E. Shaw, Robyn J. Tapp

Research output: Contribution to journalReview articlepeer-review

58 Citations (Scopus)


The prevention of type 2 diabetes mellitus (T2DM) is a target priority for the WHO and the United Nations and is a key priority in the 2018 Berlin Declaration, which is a global call for early actions related to T2DM. Health-care policies advocate that individuals at high risk of developing T2DM undertake lifestyle modification, irrespective of whether the prediabetes phenotype is defined by hyperglycaemia in the postprandial state (impaired glucose tolerance) and/or fasting state (impaired fasting glucose) or by intermediate HbA1c levels. However, current evidence indicates that diabetes prevention programmes based on lifestyle change have not been successful in preventing T2DM in individuals with isolated impaired fasting glucose. We propose that further research is needed to identify effective lifestyle interventions for individuals with isolated impaired fasting glucose. Furthermore, we call for the identification of innovative approaches that better identify people with impaired glucose tolerance, who benefit from the currently available lifestyle-based diabetes prevention programmes.

Original languageEnglish
Pages (from-to)395–400
Number of pages6
JournalNature Reviews Endocrinology
Issue number7
Early online date14 Feb 2020
Publication statusPublished - Jul 2020
Externally publishedYes


  • Lifestyle modification
  • Pre-diabetes
  • Type 2 diabetes
  • Weight management

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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