BDNF Val66Met and 5-HTTLPR genotype are each associated with visual scanning patterns of faces in young children

A. Christou, Y. Wallis, H. Bair, Hayley Crawford, S. Frisson, M.P. Zeegers, J.P. McCleery

    Research output: Contribution to journalArticle

    4 Citations (Scopus)
    15 Downloads (Pure)

    Abstract

    Previous studies have documented both neuroplasticity-related BDNF Val66Met and emotion regulation-related 5-HTTLPR polymorphisms as genetic variants that contribute to the processing of emotions from faces. More specifically, research has shown the BDNF Met allele and the 5-HTTLPR Short allele to be associated with mechanisms of negative affectivity that relate to susceptibility for psychopathology. We examined visual scanning pathways in response to angry, happy, and neutral faces in relation to BDNF Val66Met and 5-HTTLPR genotyping in 49 children aged 4–7 years. Analyses revealed that variations in the visual processing of facial expressions of anger interacted with BDNF Val66Met genotype, such that children who carried at least one low neuroplasticity Met allele exhibited a vigilance–avoidance pattern of visual scanning compared to homozygotes for the high neuroplasticity Val allele. In a separate investigation of eye gaze towards the eye versus mouth regions of neutral faces, we observed that short allele 5-HTTLPR carriers exhibited reduced looking at the eye region compared with those with the higher serotonin uptake Long allele. Together, these findings suggest that genetic mechanisms early in life may influence the establishment of patterns of visual scanning of environmental stressors, which in conjunction with other factors such as negative life events, may lead to psychological difficulties and disorders in the later adolescent and adult years.
    Original languageEnglish
    Pages (from-to)175
    JournalFrontiers in Behavioral Neuroscience
    Volume9
    DOIs
    Publication statusPublished - 13 Jul 2015

    Fingerprint

    Brain-Derived Neurotrophic Factor
    Alleles
    Genotype
    Neuronal Plasticity
    Emotions
    Facial Expression
    Visual Pathways
    Anger
    Homozygote
    Psychopathology
    Mouth
    Serotonin
    Psychology
    Research

    Bibliographical note

    © 2015 Christou, Wallis, Bair, Crawford, Frisson, Zeegers and McCleery. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    Keywords

    • BDNF Val66Met
    • 5-HTTLPR
    • eye movement
    • emotional face
    • facial features
    • affective neuroscience
    • early childhood

    Cite this

    BDNF Val66Met and 5-HTTLPR genotype are each associated with visual scanning patterns of faces in young children. / Christou, A.; Wallis, Y.; Bair, H.; Crawford, Hayley; Frisson, S.; Zeegers, M.P.; McCleery, J.P.

    In: Frontiers in Behavioral Neuroscience, Vol. 9, 13.07.2015, p. 175.

    Research output: Contribution to journalArticle

    Christou, A. ; Wallis, Y. ; Bair, H. ; Crawford, Hayley ; Frisson, S. ; Zeegers, M.P. ; McCleery, J.P. / BDNF Val66Met and 5-HTTLPR genotype are each associated with visual scanning patterns of faces in young children. In: Frontiers in Behavioral Neuroscience. 2015 ; Vol. 9. pp. 175.
    @article{e89a0127d4894142aee8eb0928baf8d4,
    title = "BDNF Val66Met and 5-HTTLPR genotype are each associated with visual scanning patterns of faces in young children",
    abstract = "Previous studies have documented both neuroplasticity-related BDNF Val66Met and emotion regulation-related 5-HTTLPR polymorphisms as genetic variants that contribute to the processing of emotions from faces. More specifically, research has shown the BDNF Met allele and the 5-HTTLPR Short allele to be associated with mechanisms of negative affectivity that relate to susceptibility for psychopathology. We examined visual scanning pathways in response to angry, happy, and neutral faces in relation to BDNF Val66Met and 5-HTTLPR genotyping in 49 children aged 4–7 years. Analyses revealed that variations in the visual processing of facial expressions of anger interacted with BDNF Val66Met genotype, such that children who carried at least one low neuroplasticity Met allele exhibited a vigilance–avoidance pattern of visual scanning compared to homozygotes for the high neuroplasticity Val allele. In a separate investigation of eye gaze towards the eye versus mouth regions of neutral faces, we observed that short allele 5-HTTLPR carriers exhibited reduced looking at the eye region compared with those with the higher serotonin uptake Long allele. Together, these findings suggest that genetic mechanisms early in life may influence the establishment of patterns of visual scanning of environmental stressors, which in conjunction with other factors such as negative life events, may lead to psychological difficulties and disorders in the later adolescent and adult years.",
    keywords = "BDNF Val66Met, 5-HTTLPR, eye movement, emotional face, facial features, affective neuroscience, early childhood",
    author = "A. Christou and Y. Wallis and H. Bair and Hayley Crawford and S. Frisson and M.P. Zeegers and J.P. McCleery",
    note = "{\circledC} 2015 Christou, Wallis, Bair, Crawford, Frisson, Zeegers and McCleery. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.",
    year = "2015",
    month = "7",
    day = "13",
    doi = "10.3389/fnbeh.2015.00175",
    language = "English",
    volume = "9",
    pages = "175",
    journal = "Frontiers in Behavioral Neuroscience",
    issn = "1662-5153",
    publisher = "Frontiers Media",

    }

    TY - JOUR

    T1 - BDNF Val66Met and 5-HTTLPR genotype are each associated with visual scanning patterns of faces in young children

    AU - Christou, A.

    AU - Wallis, Y.

    AU - Bair, H.

    AU - Crawford, Hayley

    AU - Frisson, S.

    AU - Zeegers, M.P.

    AU - McCleery, J.P.

    N1 - © 2015 Christou, Wallis, Bair, Crawford, Frisson, Zeegers and McCleery. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    PY - 2015/7/13

    Y1 - 2015/7/13

    N2 - Previous studies have documented both neuroplasticity-related BDNF Val66Met and emotion regulation-related 5-HTTLPR polymorphisms as genetic variants that contribute to the processing of emotions from faces. More specifically, research has shown the BDNF Met allele and the 5-HTTLPR Short allele to be associated with mechanisms of negative affectivity that relate to susceptibility for psychopathology. We examined visual scanning pathways in response to angry, happy, and neutral faces in relation to BDNF Val66Met and 5-HTTLPR genotyping in 49 children aged 4–7 years. Analyses revealed that variations in the visual processing of facial expressions of anger interacted with BDNF Val66Met genotype, such that children who carried at least one low neuroplasticity Met allele exhibited a vigilance–avoidance pattern of visual scanning compared to homozygotes for the high neuroplasticity Val allele. In a separate investigation of eye gaze towards the eye versus mouth regions of neutral faces, we observed that short allele 5-HTTLPR carriers exhibited reduced looking at the eye region compared with those with the higher serotonin uptake Long allele. Together, these findings suggest that genetic mechanisms early in life may influence the establishment of patterns of visual scanning of environmental stressors, which in conjunction with other factors such as negative life events, may lead to psychological difficulties and disorders in the later adolescent and adult years.

    AB - Previous studies have documented both neuroplasticity-related BDNF Val66Met and emotion regulation-related 5-HTTLPR polymorphisms as genetic variants that contribute to the processing of emotions from faces. More specifically, research has shown the BDNF Met allele and the 5-HTTLPR Short allele to be associated with mechanisms of negative affectivity that relate to susceptibility for psychopathology. We examined visual scanning pathways in response to angry, happy, and neutral faces in relation to BDNF Val66Met and 5-HTTLPR genotyping in 49 children aged 4–7 years. Analyses revealed that variations in the visual processing of facial expressions of anger interacted with BDNF Val66Met genotype, such that children who carried at least one low neuroplasticity Met allele exhibited a vigilance–avoidance pattern of visual scanning compared to homozygotes for the high neuroplasticity Val allele. In a separate investigation of eye gaze towards the eye versus mouth regions of neutral faces, we observed that short allele 5-HTTLPR carriers exhibited reduced looking at the eye region compared with those with the higher serotonin uptake Long allele. Together, these findings suggest that genetic mechanisms early in life may influence the establishment of patterns of visual scanning of environmental stressors, which in conjunction with other factors such as negative life events, may lead to psychological difficulties and disorders in the later adolescent and adult years.

    KW - BDNF Val66Met

    KW - 5-HTTLPR

    KW - eye movement

    KW - emotional face

    KW - facial features

    KW - affective neuroscience

    KW - early childhood

    U2 - 10.3389/fnbeh.2015.00175

    DO - 10.3389/fnbeh.2015.00175

    M3 - Article

    VL - 9

    SP - 175

    JO - Frontiers in Behavioral Neuroscience

    JF - Frontiers in Behavioral Neuroscience

    SN - 1662-5153

    ER -