TY - JOUR
T1 - Bariatric surgery reduces branched-chain amino acids’ levels
T2 - A systematic review and meta-analysis
AU - Barati-Boldaji, Reza
AU - Clark, Cain
AU - Babajafari, Siavash
AU - Kazari, Asma
AU - Esmaeilinezhad, Zahra
AU - Mazidi, Mohsen
AU - Ofori-Asenso, Richard
AU - Haghighat, Neda
AU - Shafiee, Maryam
AU - Mohammad Mazloomi, Seyed
PY - 2020/10/29
Y1 - 2020/10/29
N2 - Bariatric surgery is a metabolic surgery known to be an efficient treatment for weight loss, with adequate long-term maintenance. Interestingly, some studies have reported a reduction in branched chained amino acids (BCAAs) after bariatric surgery, which putatively contributes to post-surgical metabolic improvement. The current systematic review and meta-analysis investigated the effect of bariatric surgery on the level of BCAAs. PubMed, SCOPUS, EMBASE, and Web of Science databases were searched from their inception to July 2019. All clinical trials which investigated the effect of bariatric surgery on the levels of valine, leucine, and isoleucine, for more than one week, were included. Nine studies (11 effect sizes) were analyzed via meta-analytical techniques using random-effects models. The pooled data suggested that bariatric surgery significantly reduced the valine (standardized mean difference [SMD]: - 1.89, 95% CI: -2.79, -0.99, I2 = 90.9%), leucine (SMD: -0.96, 95% CI: -1.48, -0.44, I2 = 72.4%), and isoleucine (SMD: -0.58, 95% CI: -0.84, -0.31, I2 = 66.3%) levels after surgery compared with before the surgery. Overall, bariatric surgery significantly reduced the levels of valine, leucine, and isoleucine compared with before the surgery. Further large-scale and homogenous trials are needed to better discern the generalizability of our findings.
AB - Bariatric surgery is a metabolic surgery known to be an efficient treatment for weight loss, with adequate long-term maintenance. Interestingly, some studies have reported a reduction in branched chained amino acids (BCAAs) after bariatric surgery, which putatively contributes to post-surgical metabolic improvement. The current systematic review and meta-analysis investigated the effect of bariatric surgery on the level of BCAAs. PubMed, SCOPUS, EMBASE, and Web of Science databases were searched from their inception to July 2019. All clinical trials which investigated the effect of bariatric surgery on the levels of valine, leucine, and isoleucine, for more than one week, were included. Nine studies (11 effect sizes) were analyzed via meta-analytical techniques using random-effects models. The pooled data suggested that bariatric surgery significantly reduced the valine (standardized mean difference [SMD]: - 1.89, 95% CI: -2.79, -0.99, I2 = 90.9%), leucine (SMD: -0.96, 95% CI: -1.48, -0.44, I2 = 72.4%), and isoleucine (SMD: -0.58, 95% CI: -0.84, -0.31, I2 = 66.3%) levels after surgery compared with before the surgery. Overall, bariatric surgery significantly reduced the levels of valine, leucine, and isoleucine compared with before the surgery. Further large-scale and homogenous trials are needed to better discern the generalizability of our findings.
KW - leucine
KW - isoleucine
KW - Valine
KW - bariatric surgery
KW - gastric bypass
U2 - 10.1016/j.nutres.2020.10.008
DO - 10.1016/j.nutres.2020.10.008
M3 - Review article
SP - (in press)
JO - Nutrition Research
JF - Nutrition Research
ER -