B-cell responses to vaccination at the extremes of age

Claire Anne Siegrist, Richard Aspinall

Research output: Contribution to journalReview article

319 Citations (Scopus)

Abstract

Infants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalNature Reviews Immunology
Volume9
Issue number3
DOIs
Publication statusPublished - 1 Mar 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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