Associations between the Gut Microbiome and Metabolic, Inflammatory and Appetitive Effects of Sleeve Gastrectomy

Holly Naomi Brown, Thomas Barber, Derek Renshaw, Sebastien Farnaud, Dominic Oduro-Donkor, Mark Turner

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
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The complex and multifactorial etiology of obesity creates challenges for its effective long-term management. Increasingly, the gut microbiome is reported to play a key role in the maintenance of host health and wellbeing, with its dysregulation associated with chronic diseases such as obesity. The gut microbiome is hypothesized to contribute to obesity development and pathogenesis via several pathways involving food digestion, energy harvest and storage, production of metabolites influencing satiety, maintenance of gut barrier integrity, and bile acid metabolism. Moreover, the gut microbiome likely contributes to the metabolic, inflammatory, and satiety benefits and sustained weight-loss effects following bariatric procedures such as sleeve gastrectomy. While the field of gut microbiome research in relation to obesity and sleeve gastrectomy outcomes is largely in its infancy, the gut microbiome nonetheless holds great potential for understanding some of the mechanisms behind sleeve gastrectomy outcomes as well as for optimizing post-surgery benefits. This review will explore the current literature within the field as well as discuss the current limitations, including the small sample size, variability in methodological approaches, and lack of associative data, which need to be addressed in future studies.
Original languageEnglish
Article numbere13600
Number of pages13
JournalObesity Reviews
Issue number9
Early online date13 Jul 2023
Publication statusPublished - Sept 2023

Bibliographical note

© 2023 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.


The authors would like to acknowledge studentship funding provided by Coventry University for this research.


  • gut microbiome
  • obesity
  • sleeve gastrectomy


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