Associations between sleep-related heart rate variability and both sleep and symptoms of depression and anxiety: A systematic review

Arron Taylor Lund Correia, Gosia Lipinska, H.G. Laurie Rauche, Philippa Forshaw, Laura Roden, Dale E Rae

    Research output: Contribution to journalReview articlepeer-review

    3 Citations (Scopus)
    134 Downloads (Pure)

    Abstract

    There is a bidirectional relationship between poor sleep and both mood- and anxiety-related disorders, which are among leading global health concerns. Additionally, both disordered sleep and these psychiatric disorders appear to be independently associated with altered autonomic nervous system (ANS) function. We hypothesise that ANS dysregulation during sleep may explain part of the relationship between poor sleep and mood- and anxiety-related disorders. Heart rate variability (HRV) is a frequently used marker of ANS function and gives an indication of ANS input to the heart - in particular, of the relative contributions of sympathetic and parasympathetic activity. A systematic review of PubMed, Scopus and Web of Science yielded 41 studies dealing with sleep, mood- and anxiety-related disorders and sleep-related HRV. Hyperarousal during sleep, reflecting a predominance of sympathetic activation and indicative of ANS dysregulation, may be an important factor in the association between poor sleep and mood-related disorders. Longitudinal studies and mediation analyses are necessary to further understand the potential mediating role of ANS dysregulation on the relationship between poor sleep and mood- and anxiety-related disorders.

    Original languageEnglish
    Pages (from-to)106-117
    Number of pages12
    JournalSleep Medicine
    Volume101
    Early online date25 Oct 2022
    DOIs
    Publication statusPublished - Jan 2023

    Bibliographical note

    © 2023, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

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    This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

    Funder

    This work is based on research funded by the National Research Foundation of South Africa (Grant no. 122508).

    Keywords

    • Anxiety
    • Autonomic nervous system
    • Depression
    • Heart rate variability (HRV)
    • Insomnia
    • PTSD
    • Sleep

    ASJC Scopus subject areas

    • Medicine(all)

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