Associations between sleep-related heart rate variability and both sleep and symptoms of depression and anxiety: A systematic review

Arron Taylor Lund Correia; Gosia Lipinska; H.G. Laurie Rauche; Philippa Forshaw; Laura Roden; Dale E Rae

doi:10.1016/j.sleep.2022.10.018

Associations between sleep-related heart rate variability and both sleep and symptoms of depression and anxiety: A systematic review

Arron Taylor Lund Correia, Gosia Lipinska, H.G. Laurie Rauche, Philippa Forshaw, Laura Roden, Dale E Rae

University of Cape Town

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

266 Downloads (Pure)

Abstract

There is a bidirectional relationship between poor sleep and both mood- and anxiety-related disorders, which are among leading global health concerns. Additionally, both disordered sleep and these psychiatric disorders appear to be independently associated with altered autonomic nervous system (ANS) function. We hypothesise that ANS dysregulation during sleep may explain part of the relationship between poor sleep and mood- and anxiety-related disorders. Heart rate variability (HRV) is a frequently used marker of ANS function and gives an indication of ANS input to the heart - in particular, of the relative contributions of sympathetic and parasympathetic activity. A systematic review of PubMed, Scopus and Web of Science yielded 41 studies dealing with sleep, mood- and anxiety-related disorders and sleep-related HRV. Hyperarousal during sleep, reflecting a predominance of sympathetic activation and indicative of ANS dysregulation, may be an important factor in the association between poor sleep and mood-related disorders. Longitudinal studies and mediation analyses are necessary to further understand the potential mediating role of ANS dysregulation on the relationship between poor sleep and mood- and anxiety-related disorders.

Original language	English
Pages (from-to)	106-117
Number of pages	12
Journal	Sleep Medicine
Volume	101
Early online date	25 Oct 2022
DOIs	https://doi.org/10.1016/j.sleep.2022.10.018
Publication status	Published - Jan 2023

Bibliographical note

© 2023, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

Funder

This work is based on research funded by the National Research Foundation of South Africa (Grant no. 122508).

Keywords

Anxiety
Autonomic nervous system
Depression
Heart rate variability (HRV)
Insomnia
PTSD
Sleep

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/j.sleep.2022.10.018

Post-PrintAccepted author manuscript, 1.33 MBLicence: CC BY-NC-ND

Cite this

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title = "Associations between sleep-related heart rate variability and both sleep and symptoms of depression and anxiety: A systematic review",

abstract = "There is a bidirectional relationship between poor sleep and both mood- and anxiety-related disorders, which are among leading global health concerns. Additionally, both disordered sleep and these psychiatric disorders appear to be independently associated with altered autonomic nervous system (ANS) function. We hypothesise that ANS dysregulation during sleep may explain part of the relationship between poor sleep and mood- and anxiety-related disorders. Heart rate variability (HRV) is a frequently used marker of ANS function and gives an indication of ANS input to the heart - in particular, of the relative contributions of sympathetic and parasympathetic activity. A systematic review of PubMed, Scopus and Web of Science yielded 41 studies dealing with sleep, mood- and anxiety-related disorders and sleep-related HRV. Hyperarousal during sleep, reflecting a predominance of sympathetic activation and indicative of ANS dysregulation, may be an important factor in the association between poor sleep and mood-related disorders. Longitudinal studies and mediation analyses are necessary to further understand the potential mediating role of ANS dysregulation on the relationship between poor sleep and mood- and anxiety-related disorders.",

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AU - Rae, Dale E

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Associations between sleep-related heart rate variability and both sleep and symptoms of depression and anxiety: A systematic review

Abstract

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Keywords

ASJC Scopus subject areas

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