Association of glucose metabolism, smoking and cardiovascular risk factors with incident peripheral arterial disease: the DESIR study

DESIR Study Group

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

AIMS: We determined the 6-year incidence of peripheral arterial disease (PAD) in a French population and assessed the association of glucose metabolism, smoking, cardiovascular risk factors and physical activity with incident PAD.

METHODS: Participants from the French Data from a Epidemiological Study on the Insulin Resistance Syndrome (DESIR) were studied. Participants analysed were 30-65 years (at baseline) and had complete data (n=3805) after 6 years of follow-up. Diabetes was diagnosed according to the 1999 WHO criteria on the basis of fasting plasma glucose results or previous diagnosis of diabetes mellitus. The ankle brachial pressure index (ABPI) and a claudication question were used to classify PAD.

RESULTS: The 6-year incidence of PAD (defined by ABPI<0.9 and or claudication present) among those with normal fasting glucose (NFG) and free of PAD at baseline was 5.1%. Among those with impaired fasting glucose (IFG) at baseline the incidence of PAD was 4.9% and among those with diabetes mellitus at baseline the incidence of PAD was 9.8%. The incidence of PAD among those who maintained NFG over 6 years was 4.7% and among those who progressed to diabetes over 6 years was 10.2%. Those who progressed from NFG or IFG to diabetes over 6 years were twice as likely to develop PAD compared to those who maintained NFG over 6 years, after adjustment for age and sex (OR (95% CI), 2.22 (1.12-4.42)). Independent risk factors for incident PAD using baseline population characteristics were diabetes (OR (95% CI) 2.11 (1.25-3.55)), systolic BP 122-135mmHg 1.06 (0.70-1.60), >135mmHg 1.54 (1.04-2.27) and current smoking 1.60 (1.10-2.34) after multivariate adjustment for age, sex, cholesterol, triglycerides and waist circumference.

CONCLUSIONS: This French study shows that those who progress to diabetes are twice as likely to develop PAD, compared to those who maintain NFG. Peripheral arterial disease is a treatable condition and more aggressive management of atherosclerotic risk factors could reduce the numbers of people who develop PAD.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalAtherosclerosis
Volume190
Issue number1
Early online date4 May 2006
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

Keywords

  • Adult
  • Aged
  • Diabetes Mellitus, Type 2/epidemiology
  • Disease Progression
  • Female
  • France/epidemiology
  • Glucose/metabolism
  • Glucose Intolerance/epidemiology
  • Humans
  • Incidence
  • Insulin Resistance
  • Logistic Models
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Peripheral Vascular Diseases/epidemiology
  • Risk Factors
  • Smoking/epidemiology

Fingerprint Dive into the research topics of 'Association of glucose metabolism, smoking and cardiovascular risk factors with incident peripheral arterial disease: the DESIR study'. Together they form a unique fingerprint.

Cite this