Association between Pre-Pregnancy BMI and Inflammatory Profile Trajectories during Pregnancy and Postpartum in Brazilian Women with Periodontitis: The IMPROVE Trial

Danilo Dias Santana, Gilberto Kac, Pedro Paulo Teixeira dos Santos, Thainá Castro da Silva, Camila Benaim, Paula Guedes Cocate, Maria Beatriz Trindade de Castro, Berit Lilienthal Heitmann, Amanda Rodrigues Amorim Adegboye

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2 Citations (Scopus)
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Abstract

This study aimed to explore the association between pre-pregnancy BMI and longitudinal changes in inflammatory markers from the second trimester of pregnancy to 6–8 weeks postpartum in women with periodontitis. This is a secondary exploratory analysis of 68 women who took part in a feasibility clinical trial in Rio de Janeiro, Brazil. Inflammatory markers included C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-10 (IL-10), and matrix metalloproteinase-9 (MMP-9) blood concentrations at 11–22 (T0) and 30–36 gestational weeks (T1), and 6–8 weeks postpartum (T3). Longitudinal generalised linear mixed-effects models were used to identify possible associations between pre-pregnancy BMI and changes in concentrations of inflammatory markers. Pre-pregnancy excess weight (β = 4.39; 95% CI, 2.12–6.65) was significantly associated with increased CRP levels from pregnancy to postpartum. There were no significant associations between pre-pregnancy BMI and longitudinal changes in IL-6, IL-10 and MMP-9. Our findings provide evidence that a higher pre-pregnancy BMI may lead to increases in CRP levels during pregnancy in women with periodontitis, irrespective of the severity of clinical periodontal parameters. Further studies need to investigate if predictors of changes in inflammatory markers can be used as prognostic factors for gestational outcomes.
Original languageEnglish
Article number2705
Number of pages14
JournalInternational Journal of Environmental Research and Public Health
Volume19
Issue number5
DOIs
Publication statusPublished - 25 Feb 2022

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Funder

Funding: This work was supported by the National Council for Scientific and Technological Development (CNPq) (Grant number 401314/2014-6) from Brazil, the Danish Dairy Research Foundation, and via an in-kind donation from Arla Foods Ingredients from Denmark.

Keywords

  • pre-pregnancy BMI
  • inflammation
  • periodontitis
  • pregnacy
  • postpartum

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