Association between PM10 exposure and risk of myocardial infarction in adults: A systematic review and meta-analysis

Kleiton  Strobl; Syed Asad  Irfan; Hassan  Masood; Noor  Latif; Om Kurmi

doi:10.1371/journal.pone.0301374

Association between PM₁₀ exposure and risk of myocardial infarction in adults: A systematic review and meta-analysis

Kleiton Strobl
, Syed Asad Irfan
, Hassan Masood
, Noor Latif
, Om Kurmi

McMaster University

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

20 Downloads (Pure)

Abstract

Background: Air pollution has several negative health effects. Particulate matter (PM) is a pollutant that is often linked to health adversities. PM_2.5 (PM with an aerodynamic diameter of ≤2.5μm) exposure has been associated with negative cardiovascular (CV) outcomes. However, the impact of PM₁₀ (PM with an aerodynamic diameter of ≤10μm) exposure is often overlooked due to its limited ability to pass the alveolar barrier. This study aims to assess the association between PM₁₀ exposure and risk of myocardial infarction (MI) amongst adults (≥18 years of age) as this has been poorly studied.

Methods: The study protocol was published on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023409796) on March 31, 2023. Literature searches were conducted on 4 databases (Ovid Medline, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and Web of Science) on January 17, 2023, for studies looking at associations between PM and MI. English studies from all time periods were assessed. Studies selected for review were time-series, case-crossover, and cohort studies which investigated the risk of MI as an outcome upon PM₁₀ exposure. The quality of evidence was assessed using Cochrane’s Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Data for different risk outcomes (risk ratio (RR), odds ratio (OR), hazard ratio (HR)) and 3 lags was meta-analyzed using an inverse variance statistical analysis using a random effects model. The pooled effect sizes and the 95% confidence intervals (CIs) were reported in forest plots.

Results: Among the 1,099 studies identified, 41 were included for review and 23 were deemed eligible for meta-analysis. Our analysis revealed that there is an increased risk (OR=1.01; 95% CI:1.00 - 1.02) of MI with a 10 μg/m³ increase in PM₁₀ after a lag 0 and lag 1 delay.

Conclusions: Our findings indicate that PM₁₀ exposure is associated with an increased risk of MI. This can aid in informing environmental policy-making, personal-level preventative measures, and global public health action.

Original language	English
Article number	e0301374
Pages (from-to)	e0301374
Number of pages	17
Journal	PLoS ONE
Volume	19
Issue number	5
Early online date	1 May 2024
DOIs	https://doi.org/10.1371/journal.pone.0301374
Publication status	Published - May 2024

Bibliographical note

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Air Pollutants - adverse effects
Air Pollution - adverse effects
Environmental Exposure - adverse effects
Humans
Myocardial Infarction - epidemiology - etiology - chemically induced
Particulate Matter - adverse effects
Risk Factors

Access to Document

10.1371/journal.pone.0301374Licence: CC BY

Kurmi2024VoRFinal published version, 1.72 MBLicence: CC BY

Cite this

@article{fe6df43d162d49b099f50a1551dfdcf8,

title = "Association between PM10 exposure and risk of myocardial infarction in adults: A systematic review and meta-analysis",

abstract = "Background: Air pollution has several negative health effects. Particulate matter (PM) is a pollutant that is often linked to health adversities. PM2.5 (PM with an aerodynamic diameter of ≤2.5μm) exposure has been associated with negative cardiovascular (CV) outcomes. However, the impact of PM10 (PM with an aerodynamic diameter of ≤10μm) exposure is often overlooked due to its limited ability to pass the alveolar barrier. This study aims to assess the association between PM10 exposure and risk of myocardial infarction (MI) amongst adults (≥18 years of age) as this has been poorly studied. Methods: The study protocol was published on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023409796) on March 31, 2023. Literature searches were conducted on 4 databases (Ovid Medline, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and Web of Science) on January 17, 2023, for studies looking at associations between PM and MI. English studies from all time periods were assessed. Studies selected for review were time-series, case-crossover, and cohort studies which investigated the risk of MI as an outcome upon PM10 exposure. The quality of evidence was assessed using Cochrane{\textquoteright}s Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Data for different risk outcomes (risk ratio (RR), odds ratio (OR), hazard ratio (HR)) and 3 lags was meta-analyzed using an inverse variance statistical analysis using a random effects model. The pooled effect sizes and the 95\% confidence intervals (CIs) were reported in forest plots. Results: Among the 1,099 studies identified, 41 were included for review and 23 were deemed eligible for meta-analysis. Our analysis revealed that there is an increased risk (OR=1.01; 95\% CI:1.00 - 1.02) of MI with a 10 μg/m3 increase in PM10 after a lag 0 and lag 1 delay. Conclusions: Our findings indicate that PM10 exposure is associated with an increased risk of MI. This can aid in informing environmental policy-making, personal-level preventative measures, and global public health action. ",

keywords = "Adult, Air Pollutants - adverse effects, Air Pollution - adverse effects, Environmental Exposure - adverse effects, Humans, Myocardial Infarction - epidemiology - etiology - chemically induced, Particulate Matter - adverse effects, Risk Factors",

author = "Kleiton Strobl and Irfan, \{Syed Asad\} and Hassan Masood and Noor Latif and Om Kurmi",

note = "This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2024",

month = may,

doi = "10.1371/journal.pone.0301374",

language = "English",

volume = "19",

pages = "e0301374",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "5",

}

TY - JOUR

T1 - Association between PM10 exposure and risk of myocardial infarction in adults

T2 - A systematic review and meta-analysis

AU - Strobl, Kleiton

AU - Irfan, Syed Asad

AU - Masood, Hassan

AU - Latif, Noor

AU - Kurmi, Om

N1 - This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2024/5

Y1 - 2024/5

N2 - Background: Air pollution has several negative health effects. Particulate matter (PM) is a pollutant that is often linked to health adversities. PM2.5 (PM with an aerodynamic diameter of ≤2.5μm) exposure has been associated with negative cardiovascular (CV) outcomes. However, the impact of PM10 (PM with an aerodynamic diameter of ≤10μm) exposure is often overlooked due to its limited ability to pass the alveolar barrier. This study aims to assess the association between PM10 exposure and risk of myocardial infarction (MI) amongst adults (≥18 years of age) as this has been poorly studied. Methods: The study protocol was published on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023409796) on March 31, 2023. Literature searches were conducted on 4 databases (Ovid Medline, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and Web of Science) on January 17, 2023, for studies looking at associations between PM and MI. English studies from all time periods were assessed. Studies selected for review were time-series, case-crossover, and cohort studies which investigated the risk of MI as an outcome upon PM10 exposure. The quality of evidence was assessed using Cochrane’s Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Data for different risk outcomes (risk ratio (RR), odds ratio (OR), hazard ratio (HR)) and 3 lags was meta-analyzed using an inverse variance statistical analysis using a random effects model. The pooled effect sizes and the 95% confidence intervals (CIs) were reported in forest plots. Results: Among the 1,099 studies identified, 41 were included for review and 23 were deemed eligible for meta-analysis. Our analysis revealed that there is an increased risk (OR=1.01; 95% CI:1.00 - 1.02) of MI with a 10 μg/m3 increase in PM10 after a lag 0 and lag 1 delay. Conclusions: Our findings indicate that PM10 exposure is associated with an increased risk of MI. This can aid in informing environmental policy-making, personal-level preventative measures, and global public health action.

AB - Background: Air pollution has several negative health effects. Particulate matter (PM) is a pollutant that is often linked to health adversities. PM2.5 (PM with an aerodynamic diameter of ≤2.5μm) exposure has been associated with negative cardiovascular (CV) outcomes. However, the impact of PM10 (PM with an aerodynamic diameter of ≤10μm) exposure is often overlooked due to its limited ability to pass the alveolar barrier. This study aims to assess the association between PM10 exposure and risk of myocardial infarction (MI) amongst adults (≥18 years of age) as this has been poorly studied. Methods: The study protocol was published on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023409796) on March 31, 2023. Literature searches were conducted on 4 databases (Ovid Medline, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and Web of Science) on January 17, 2023, for studies looking at associations between PM and MI. English studies from all time periods were assessed. Studies selected for review were time-series, case-crossover, and cohort studies which investigated the risk of MI as an outcome upon PM10 exposure. The quality of evidence was assessed using Cochrane’s Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Data for different risk outcomes (risk ratio (RR), odds ratio (OR), hazard ratio (HR)) and 3 lags was meta-analyzed using an inverse variance statistical analysis using a random effects model. The pooled effect sizes and the 95% confidence intervals (CIs) were reported in forest plots. Results: Among the 1,099 studies identified, 41 were included for review and 23 were deemed eligible for meta-analysis. Our analysis revealed that there is an increased risk (OR=1.01; 95% CI:1.00 - 1.02) of MI with a 10 μg/m3 increase in PM10 after a lag 0 and lag 1 delay. Conclusions: Our findings indicate that PM10 exposure is associated with an increased risk of MI. This can aid in informing environmental policy-making, personal-level preventative measures, and global public health action.

KW - Adult

KW - Air Pollutants - adverse effects

KW - Air Pollution - adverse effects

KW - Environmental Exposure - adverse effects

KW - Humans

KW - Myocardial Infarction - epidemiology - etiology - chemically induced

KW - Particulate Matter - adverse effects

KW - Risk Factors

UR - https://www.scopus.com/pages/publications/85192004654

U2 - 10.1371/journal.pone.0301374

DO - 10.1371/journal.pone.0301374

M3 - Article

SN - 1932-6203

VL - 19

SP - e0301374

JO - PLoS ONE

JF - PLoS ONE

IS - 5

M1 - e0301374

ER -