Association between heart rate variability and haemodynamic response to exercise in chronic heart failure

Aaron Koshy, Nduka C Okwose, David Nunan, Anet Toms, David A Brodie, Patrick Doherty, Petar Seferovic, Arsen Ristic, Lazar Velicki, Nenad Filipovic, Dejana Popovic, Jane Skinner, Kristian Bailey, Guy A MacGowan, Djordje G Jakovljevic

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Heart rate variability (HRV) and haemodynamic response to exercise (i.e. peak cardiac power output) are strong predictors of mortality in heart failure. The present study assessed the relationship between measures of HRV and peak cardiac power output.

DESIGN: In a prospective observational study of 33 patients (age 54 ± 16 years) with chronic heart failure with reduced left ventricular ejection fraction (29 ± 11%), measures of the HRV (i.e. R-R interval and standard deviation of normal R-R intervals, SDNN) were recorded in a supine position. All patients underwent maximal graded cardiopulmonary exercise testing with non-invasive (inert gas rebreathing) cardiac output assessment. Cardiac power output, expressed in watts, was calculated as the product of cardiac output and mean arterial blood pressure.

RESULTS: The mean RR and SDNN were 837 ± 166 and 96 ± 29 ms, peak exercise cardiac power output 2.28 ± 0.85 watts, cardiac output 10.34 ± 3.14 L/min, mean arterial blood pressure 98 ± 14 mmHg, stroke volume 91.43 ± 40.77 mL/beat, and oxygen consumption 19.0 ± 5.6 mL/kg/min. There was a significant but only moderate relationship between the RR interval and peak exercise cardiac power output (r = 0.43, p = .013), cardiac output (r = 0.35, p = .047), and mean arterial blood pressure (r = 0.45, p = .009). The SDNN correlated with peak cardiac power output (r = 0.42, p = .016), mean arterial blood arterial (r = 0.41, p = .019), and stroke volume (r = 0.35, p = .043).

CONCLUSIONS: Moderate strength of the relationship between measures of HRV and cardiac response to exercise suggests that cardiac autonomic function is not good indicator of overall function and pumping capability of the heart in chronic heart failure.

Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalScandinavian Cardiovascular Journal
Volume53
Issue number2
Early online date8 Apr 2019
DOIs
Publication statusPublished - Apr 2019
Externally publishedYes

Keywords

  • Adult
  • Aged
  • Arterial Pressure
  • Autonomic Nervous System/physiopathology
  • Cardiac Output
  • Chronic Disease
  • Exercise Tolerance
  • Female
  • Heart/innervation
  • Heart Failure/diagnosis
  • Heart Rate
  • Humans
  • Male
  • Middle Aged
  • Models, Cardiovascular
  • Prospective Studies
  • Stroke Volume
  • Time Factors
  • Ventricular Function, Left

Fingerprint Dive into the research topics of 'Association between heart rate variability and haemodynamic response to exercise in chronic heart failure'. Together they form a unique fingerprint.

  • Cite this