Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation

L. La Pensée; S. Sabbani; R. Sharma; I. Bhamra; E. Shore; A.E. Chadwick; N.G. Berry; J. Firman; N.C. Araujo; L. Cabral; M.L.S. Cristiano; C. Bateman; Omar Janneh; A. Gavrila; Y.H. Wu; Afthab Hussain; S.A. Ward; P.A. Stocks; R. Cosstick; P.M. O'Neill

doi:10.1002/cmdc.201200536

Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation

L. La Pensée, S. Sabbani, R. Sharma, I. Bhamra, E. Shore, A.E. Chadwick, N.G. Berry, J. Firman, N.C. Araujo, L. Cabral, M.L.S. Cristiano, C. Bateman, Omar Janneh, A. Gavrila, Y.H. Wu, Afthab Hussain, S.A. Ward, P.A. Stocks, R. Cosstick, P.M. O'Neill

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Artemisinins are currently in phase I–II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin–polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.

Original language	English
Pages (from-to)	709-718
Journal	ChemMedChem
Volume	8
Issue number	5
DOIs	https://doi.org/10.1002/cmdc.201200536
Publication status	Published - 2013

Bibliographical note

The full text of this item is not available from the repository.
This is the peer reviewed version of the following article: La Pensée, L. , Sabbani, S. , Sharma, R. , Bhamra, I. , Shore, E. , Chadwick, A.E. , Berry, N.G. , Firman, J. , Araujo, N.C. , Cabral, L. , Cristiano, M.L.S. , Bateman, C. , Janneh, O. , Gavrila, A. , Wu, Y.H. , Hussain, A. , Ward, S.A. , Stocks, P.A. , Cosstick, R. and O'Neill, P.M. (2013) Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation. ChemMedChem, volume 8 (5): 709-718, which has been published in final form at http://dx.doi.org/10.1002/cmdc.201200536. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.

Keywords

artemisinin
binding studies
cytotoxicity
DNA
molecular modelling

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cmdc.201200536

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La Pensée, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., Berry, N. G., Firman, J., Araujo, N. C., Cabral, L., Cristiano, M. L. S., Bateman, C., Janneh, O., Gavrila, A., Wu, Y. H., Hussain, A., Ward, S. A., Stocks, P. A., Cosstick, R., & O'Neill, P. M. (2013). Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation. ChemMedChem, 8(5), 709-718. https://doi.org/10.1002/cmdc.201200536

La Pensée, L, Sabbani, S, Sharma, R, Bhamra, I, Shore, E, Chadwick, AE, Berry, NG, Firman, J, Araujo, NC, Cabral, L, Cristiano, MLS, Bateman, C, Janneh, O, Gavrila, A, Wu, YH, Hussain, A, Ward, SA, Stocks, PA, Cosstick, R & O'Neill, PM 2013, 'Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation', ChemMedChem, vol. 8, no. 5, pp. 709-718. https://doi.org/10.1002/cmdc.201200536

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abstract = "Artemisinins are currently in phase I–II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin–polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy. ",

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AU - Sharma, R.

AU - Bhamra, I.

AU - Shore, E.

AU - Chadwick, A.E.

AU - Berry, N.G.

AU - Firman, J.

AU - Araujo, N.C.

AU - Cabral, L.

AU - Cristiano, M.L.S.

AU - Bateman, C.

AU - Janneh, Omar

AU - Gavrila, A.

AU - Wu, Y.H.

AU - Hussain, Afthab

AU - Ward, S.A.

AU - Stocks, P.A.

AU - Cosstick, R.

AU - O'Neill, P.M.

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AB - Artemisinins are currently in phase I–II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin–polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.

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KW - binding studies

KW - cytotoxicity

KW - DNA

KW - molecular modelling

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DO - 10.1002/cmdc.201200536

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JF - ChemMedChem

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ER -

Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation

Abstract

Bibliographical note

Keywords

UN SDGs

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