Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation

L. La Pensée, S. Sabbani, R. Sharma, I. Bhamra, E. Shore, A.E. Chadwick, N.G. Berry, J. Firman, N.C. Araujo, L. Cabral, M.L.S. Cristiano, C. Bateman, Omar Janneh, A. Gavrila, Y.H. Wu, Afthab Hussain, S.A. Ward, P.A. Stocks, R. Cosstick, P.M. O'Neill

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Artemisinins are currently in phase I–II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin–polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.
    Original languageEnglish
    Pages (from-to)709-718
    JournalChemMedChem
    Volume8
    Issue number5
    DOIs
    Publication statusPublished - 2013

    Bibliographical note

    The full text of this item is not available from the repository.
    This is the peer reviewed version of the following article: La Pensée, L. , Sabbani, S. , Sharma, R. , Bhamra, I. , Shore, E. , Chadwick, A.E. , Berry, N.G. , Firman, J. , Araujo, N.C. , Cabral, L. , Cristiano, M.L.S. , Bateman, C. , Janneh, O. , Gavrila, A. , Wu, Y.H. , Hussain, A. , Ward, S.A. , Stocks, P.A. , Cosstick, R. and O'Neill, P.M. (2013) Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation. ChemMedChem, volume 8 (5): 709-718, which has been published in final form at http://dx.doi.org/10.1002/cmdc.201200536. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.

    Keywords

    • artemisinin
    • binding studies
    • cytotoxicity
    • DNA
    • molecular modelling

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  • Cite this

    La Pensée, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., ... O'Neill, P. M. (2013). Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation. ChemMedChem, 8(5), 709-718. https://doi.org/10.1002/cmdc.201200536