An Exercise-Induced Improvement In Isolated Skeletal Muscle Contractility Does Not Affect The Performance-Enhancing Benefit Of 70 [Mu]M Caffeine Treatment.

Jason Tallis; Matthew F. Higgins; Valerie Cox; Michael Duncan; Rob James

doi:10.1242/jeb.190132

An Exercise-Induced Improvement In Isolated Skeletal Muscle Contractility Does Not Affect The Performance-Enhancing Benefit Of 70 [Mu]M Caffeine Treatment.

Jason Tallis, Matthew F. Higgins, Valerie Cox, Michael Duncan, Rob James

University of Derby

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

32 Downloads (Pure)

Abstract

This study aimed to examine the effects of exercise-induced increases in skeletal muscle contractile performance on isolated skeletal muscle caffeine sensitivity. 30-week old CD1 mice (n=28) either acted as controls or underwent eight weeks of voluntary wheel running. Following the treatment intervention, whole soleus (SOL) or a section of the costal diaphragm (DIA) was isolated from each mouse and tested to determine the effect of 70µM caffeine on work loop power output. Although caffeine elicited a significant increase in power of both the SOL and the DIA, relative to a non-caffeine control, the effect was not different between the experimental groups, despite the muscles of the trained group producing significantly greater muscle power. There was no significant relationship between training volume or baseline work loop power and the caffeine response. These results indicate that an exercise-induced increase in muscle performance did not influence the performance-enhancing effects of caffeine.

Original language	English
Article number	190132
Journal	Journal of Experimental Biology
Volume	221
Early online date	17 Sept 2018
DOIs	https://doi.org/10.1242/jeb.190132
Publication status	Published - 5 Nov 2018

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Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

Keywords

Ergogenic aid
Muscle ageing
Work loop
Muscle power

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10.1242/jeb.190132

Post-PrintAccepted author manuscript, 543 KBLicence: CC BY

Jason Tallis
- Centre for Physical Activity, Sport and Exercise Sciences - Associate Professor Research
Person: Teaching and Research

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title = "An Exercise-Induced Improvement In Isolated Skeletal Muscle Contractility Does Not Affect The Performance-Enhancing Benefit Of 70 [Mu]M Caffeine Treatment.",

abstract = "This study aimed to examine the effects of exercise-induced increases in skeletal muscle contractile performance on isolated skeletal muscle caffeine sensitivity. 30-week old CD1 mice (n=28) either acted as controls or underwent eight weeks of voluntary wheel running. Following the treatment intervention, whole soleus (SOL) or a section of the costal diaphragm (DIA) was isolated from each mouse and tested to determine the effect of 70µM caffeine on work loop power output. Although caffeine elicited a significant increase in power of both the SOL and the DIA, relative to a non-caffeine control, the effect was not different between the experimental groups, despite the muscles of the trained group producing significantly greater muscle power. There was no significant relationship between training volume or baseline work loop power and the caffeine response. These results indicate that an exercise-induced increase in muscle performance did not influence the performance-enhancing effects of caffeine. ",

keywords = "Ergogenic aid, Muscle ageing, Work loop, Muscle power",

author = "Jason Tallis and Higgins, {Matthew F.} and Valerie Cox and Michael Duncan and Rob James",

note = "Copyright {\textcopyright} and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. ",

year = "2018",

month = nov,

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AU - Higgins, Matthew F.

AU - Cox, Valerie

AU - Duncan, Michael

AU - James, Rob

N1 - Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

PY - 2018/11/5

Y1 - 2018/11/5

N2 - This study aimed to examine the effects of exercise-induced increases in skeletal muscle contractile performance on isolated skeletal muscle caffeine sensitivity. 30-week old CD1 mice (n=28) either acted as controls or underwent eight weeks of voluntary wheel running. Following the treatment intervention, whole soleus (SOL) or a section of the costal diaphragm (DIA) was isolated from each mouse and tested to determine the effect of 70µM caffeine on work loop power output. Although caffeine elicited a significant increase in power of both the SOL and the DIA, relative to a non-caffeine control, the effect was not different between the experimental groups, despite the muscles of the trained group producing significantly greater muscle power. There was no significant relationship between training volume or baseline work loop power and the caffeine response. These results indicate that an exercise-induced increase in muscle performance did not influence the performance-enhancing effects of caffeine.

AB - This study aimed to examine the effects of exercise-induced increases in skeletal muscle contractile performance on isolated skeletal muscle caffeine sensitivity. 30-week old CD1 mice (n=28) either acted as controls or underwent eight weeks of voluntary wheel running. Following the treatment intervention, whole soleus (SOL) or a section of the costal diaphragm (DIA) was isolated from each mouse and tested to determine the effect of 70µM caffeine on work loop power output. Although caffeine elicited a significant increase in power of both the SOL and the DIA, relative to a non-caffeine control, the effect was not different between the experimental groups, despite the muscles of the trained group producing significantly greater muscle power. There was no significant relationship between training volume or baseline work loop power and the caffeine response. These results indicate that an exercise-induced increase in muscle performance did not influence the performance-enhancing effects of caffeine.

KW - Ergogenic aid

KW - Muscle ageing

KW - Work loop

KW - Muscle power

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DO - 10.1242/jeb.190132

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VL - 221

JO - Journal of Experimental Biology

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ER -

An Exercise-Induced Improvement In Isolated Skeletal Muscle Contractility Does Not Affect The Performance-Enhancing Benefit Of 70 [Mu]M Caffeine Treatment.

Abstract

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Keywords

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